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  • A Randomized Trial of the Utility of Random Biopsies in Patients With Inflammatory Bowel Disease Rochester, Minn., Jacksonville, Fla. The proposed study is a multicenter parallel group clinical trial that will include 821 evaluable patients per group who will be randomly assigned to either high definition white light colonoscopy (HDWLC) with targeted biopsies plus 2 random biopsies in 4 segments to assess for inflammation (limited biopsy strategy) or HDWLC with targeted biopsies plus 4 biopsies every 10 cm throughout the colon, at a minimum in all segments of the colon known to have been affected by IBD at any time, regardless of the extent of disease (random biopsy strategy). Participants will be followed until total proctocolectomy or the end of the study period to determine whether the two methods of surveillance colonoscopy are associated with detection of dysplasia or sessile serrated adenoma at follow-up colonoscopy. Follow-up via chart review may continue for up to 15 years from enrollment.
  • Understanding Patients’ Current Acceptability of Artificial Intelligence and Machine Learning During Colonoscopy for Polyp Detection: A Single Center Study Rochester, Minn.

    The purpose of this study is to understand and assess patients’ current acceptability of machine learning/AI during colonoscopy for polyp detection.Our secondary aims are to determine what factors influence patients’ responses and to determine the various thresholds in adenoma detection rate (ADR) that would be acceptable to patients. 

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