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Multicenter, Randomized Phase II Trial On Palliative Radiation With Or Without Spatially Fractionated Radiotherapy Boost For Unresectable Bulky Malignancies
Scottsdale/Phoenix, AZ
Rochester, MN
The purpose of this study is to determine if the addition of a SFRT boost to standard palliative external beam RT (Group I) provides superior patient reported treatment response of the most prominent symptom related to the target lesion prior to starting the study using a standardize scale (item 4.3.4) as assessed at 1 month after completing the treatment, compared to sham SFRT followed by standard external beam RT (Group II).
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ROF2181: Prospective Comparative Effectiveness Trial Of Carbon Ion Therapy, Surgery, And Proton Therapy For The Management Of Pelvic Sarcomas (Soft Tissue/bone) Involving The Bone (The PROSPER Study)
Scottsdale/Phoenix, AZ
Jacksonville, FL
Rochester, MN
Currently, only a few international institutions use CIRT to treat pelvic bone sarcomas. Accordingly, data evaluating the potential differences in oncological outcomes, toxicities, and functional outcomes between CIRT and the more readily accessible local therapies of surgery and PT is scarce. For this reason, we propose conducting a prospective comparative effectiveness study evaluating functional outcomes, toxicities, and local control in patients with pelvic bone sarcomas treated with surgery, PT, and CIRT.
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