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Evaluate the safety and efficacy of unilateral focused ultrasound pallidotomy using the ExAblate 4000 System in the management of dyskinesia symptoms or motor fluctuations for medication refractory, advanced idiopathic Parkinson's disease.
This study is designed to evaluate the high-frequency range deep brain oscillations (HFO) as pathologic markers in patients undergoing deep brain stimulation for epilepsy or Parkinson disease. Newly developed technology allows for the chronic recording of these brain signals at the same time as clinical stimulation is occuring. We will learn both whether these HFO correlate with disease activity and whether the HFO change in response to ongoing stimulation (potentially giving insight into the underlying mechanism of action of DBS). Study participants will undergo DBS in the same way as is usually done but will receive this newer battery with ability to record brain signals.
The aim of this protocol is to design a measurement paradigm that reliably detects EEG oscillatory patterns during movement, relaxation, or imagination. These techniques will be applied to normal controls and dystonic patients to define differences in the patterns between the two groups.
The purpose of the study is to evaluate a new method of recording brain activity during surgery and to help determine the mechanism through which deep brain stimulation is helping patients.
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