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Clinical Studies

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  • EPVent 2- A Phase II Study of Mechanical Ventilation Directed by Transpulmonary Pressures (EPVent2) (EPVent2) Rochester, Minn.

    This phase II multi-centered, randomized controlled trial of mechanical ventilation directed by esophageal pressure measurement will test the primary hypothesis that using a strategy of maintaining a minimal but positive transpulmonary pressure (PTP = airway pressure minus pleural pressure) throughout the ventilatory cycle will lead to an improvement in patient survival.

  • Inhaled Hypertonic Saline for the Treatment of Acute Lung Injury Rochester, Minn.

    To determine if an inhaled hypertonic saline solution has any effect on lung function in patients with acute respiratory distress syndrome (ARDS).

  • Mechanical Ventilation Guided By Transpulmonary and Airway Driving Pressures Rochester, Minn.

    The purpose of this study is to test the correspondence between Airway Driving Pressure (DPAW; defined as plateau pressure minus positive end-expiratory pressure) and transpulmonary driving pressure (DPTP)—the quotient of tidal volume and lung compliance (CL), in response to intra-abdominal hypertension and changes in positive end-expiratory pressure during laparoscopic and robotic surgical interventions requiring intra-abdominal insufflation.