Mark D. Topazian, M.D.

Closed for Enrollment

• Endoscopic Ethanol Ablation of Communicating Pancreatic Cystic Neoplasms Rochester, Minn.

   The purpose of this study is to evaluate the effects of treating pancreas cysts that connect with the main pancreas duct with injected ethanol using endoscopic retrograde cholangiopancreatography (ERCP) and/or endoscopic ultrasound. Past studies have excluded these cysts that communicate with the main pancreatic duct, to avoid burning the main pancreatic duct with ethanol.

• Endoscopic Ultrasound-guided Ethanol Injection of Pancreatic Cystic Neoplasms Rochester, Minn.

  Cystic tumors of the pancreas are fluid-filled growths. They are often treated by surgical removal. A safe and effective non-surgical treatment is desirable. Ethanol (alcohol) injection may treat cysts by killing the lining cells of the cyst, and is an accepted treatment for cysts of other organs. In this study, participants with pancreatic cysts will undergo endoscopic ultrasound (EUS) guided ethanol injection of pancreatic cysts. This is a pilot study to assess safety and efficacy.

• Outcome of Rituximab Treatment for IgG4-Related Disease Rochester, Minn.

  The purpose of this study is to compare IgG4-related disease remission and relapse rates between patients who had induction rituximab treatment with or without follow-up maintenance rituximab therapy, at Mayo Clinic, Rochester between 1 January 2000 and 22 December 2015.

• Prostaglandin Levels in Pancreatic Cyst Fluid, Pancreatic Juice, and Resected Pancreatic Cysts Rochester, Minn.

  The purpose of this study is to determine whether COX-2 enzyme activity in pancreatic cystic neoplasms is sufficient to justify a chemoprevention study.