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Clinical Studies
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Breast Cancer Risk Assessment in Benign Breast Disease
Rochester, Minn.
The purpose of this study is to to bring molecular risk prediction for breast cancer into the clinical arena through: the establishment of a large tissue repository from a retrospective cohort of women with benign breast disease with complete and long-term clinical follow-up to identify those who developed breast cancer (cases) and those who did not (controls); the application of potential biomarkers of risk to this archival tissue set; and, the discovery of new, potentially relevant biomarkers of risk in fresh and frozen specimens of benign breast disease.
Contact Us for the Latest Status
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A Phase IB Trial of Neoadjuvant Multi-Epitope HER2 Peptide Vaccine in Patients With HER2-Expressing DCIS
Rochester, Minn.,
Jacksonville, Fla.
This phase Ib trial studies the side effects and best dose of a vaccine called H2NVAC before surgery in treating patients with HER2 expressing ductal carcinoma in situ. H2NVAC is a vaccine designed to stimulate specialized white blood cells in hopes of increasing immune response and protecting against breast cancer.
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Breast Cancer Risk Assessment in Benign Breast Disease
Jacksonville, Fla.
The purpose of this study is to to bring molecular risk prediction for breast cancer into the clinical arena through: the establishment of a large tissue repository from a retrospective cohort of women with benign breast disease with complete and long-term clinical follow-up to identify those who developed breast cancer (cases) and those who did not (controls); the application of potential biomarkers of risk to this archival tissue set; and, the discovery of new, potentially relevant biomarkers of risk in fresh and frozen specimens of benign breast disease.
Closed for Enrollment
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Benign Breast Tissue Studies
Jacksonville, Fla.,
Rochester, Minn.
This study is being done to study what regulates breast tissue growth, to better understand if there is a possible relationship between benign changes and breast cancer. Laboratory studies will search for changes in genetic material (DNA
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Breast Education through Simulation Training (BEST): Post-Mastectomy Wound and Drain Care Patient Education (BEST)
Rochester, Minn.
Plan to conduct a pilot randomized controlled trial to determine the feasibility, benefits and educational impact of using simulation for patient education (SimEd) for post-mastectomy wound and drain care, compared to current patient education practice (StdEd). This study also seeks to derive and validate a skills assessment tool specifically developed to evaluate skills acquired during the education process and compare the results of SimEd vs StdEd; we also plan to relate the scores of our assessment tool to a validated instrument that measures readiness for patient dismissal and compare their results in both study arms.
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Evaluating Surgical Treatment Related Differences in Patient Satisfaction and Health-related Quality of Life in Breast Cancer Survivors in the Long-term Survivorship Period
Rochester, Minn.
This study is being done to determine the long-term effects of different kinds of breast surgeries on women’s health-related quality of life from the patient’s perspective. The information will also provide information to assist in improving the quality of care given to patients.
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Phase IIB Randomized Trial of Oral Tamoxifen vs. Topical 4-hydroxytamoxifen gel vs. Control in Women with Atypical Hyperplasia, Lobular Carcinoma in Situ, or Increased Breast Cancer Risk
Rochester, Minn.
The purpose of this study is to analyze breast tissue changes after a short course of Tamoxifen (Tam).
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