Faculty

Amy C. Degnim, M.D.

Clinical Studies

A Phase IB Trial of Neoadjuvant Multi-epitope HER2 Peptide Vaccine in Patients with HER2-expressing DCIS Rochester, Minn., Jacksonville, Fla.
The purpose of this study is to determine the safety, effcicacy and tolerability of H2NVAC in patients with HER2-expressing DCIS in order to prevent future invasive breast cancer among patients who are diagnosed with DCIS.
A Phase IIB Randomized Trial of Oral Tamoxifen vs. Topical 4-hydroxytamoxifen Gel vs. Control in Women with Atypical Hyperplasia or Lobular Carcinoma In Situ Rochester, Minn.
The purpose of this study is to analyze breast tissue changes after a short course of Tamoxifen (Tam).
Breast Cancer Risk Assessment in Benign Breast Disease Rochester, Minn.
The purpose of this study is to to bring molecular risk prediction for breast cancer into the clinical arena through: the establishment of a large tissue repository from a retrospective cohort of women with benign breast disease with complete and long-term clinical follow-up to identify those who developed breast cancer (cases) and those who did not (controls); the application of potential biomarkers of risk to this archival tissue set; and, the discovery of new, potentially relevant biomarkers of risk in fresh and frozen specimens of benign breast disease.

Breast Cancer Risk Assessment in Benign Breast Disease Jacksonville, Fla.
The purpose of this study is to to bring molecular risk prediction for breast cancer into the clinical arena through: the establishment of a large tissue repository from a retrospective cohort of women with benign breast disease with complete and long-term clinical follow-up to identify those who developed breast cancer (cases) and those who did not (controls); the application of potential biomarkers of risk to this archival tissue set; and, the discovery of new, potentially relevant biomarkers of risk in fresh and frozen specimens of benign breast disease.

Benign Breast Tissue Studies Jacksonville, Fla., Rochester, Minn.
This study is being done to study what regulates breast tissue growth, to better understand if there is a possible relationship between benign changes and breast cancer. Laboratory studies will search for changes in genetic material (DNA
Breast Education through Simulation Training (BEST): Post-Mastectomy Wound and Drain Care Patient Education (BEST) Rochester, Minn.
Plan to conduct a pilot randomized controlled trial to determine the feasibility, benefits and educational impact of using simulation for patient education (SimEd) for post-mastectomy wound and drain care, compared to current patient education practice (StdEd). This study also seeks to derive and validate a skills assessment tool specifically developed to evaluate skills acquired during the education process and compare the results of SimEd vs StdEd; we also plan to relate the scores of our assessment tool to a validated instrument that measures readiness for patient dismissal and compare their results in both study arms.