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  • Aortic Trauma Foundation BTAI Prospective Registry Rochester, Minn.

    The purpose of this study is to establish an aggregate database of information on the diagnosis, management (acute and definitive), surveillance and outcomes following blunt thoracic aortic injury.

     

  • Diagnosis of Subclinical Urinary Tract Infections Using Advanced Microbiome Survey Techniques in High Risk Trauma Patients Rochester, Minn.

    The purpose of this study is to see if the investigators can identify early those patients who are admitted to the hospital and have a urinary tract infection (UTI) or those patients that develop a UTI during their hospitalization.

  • Prehospital Tranexamic Acid Use for Traumatic Brain Injury (TXA) Rochester, Minn.

    Primary aim: To determine the efficacy of two dosing regimens of TXA initiated in the prehospital setting in patients with moderate to severe TBI (GCS score ≤12).

    Primary hypothesis: The null hypothesis is that prehospital administration either of two dosing regimens of TXA in patients with moderate to severe TBI will not increase the proportion of patients with a favorable long-term neurologic outcome compared to placebo, based on the GOS-E at 6 months.

    Secondary aims: To determine differences between TXA and placebo in the following outcomes for patients with moderate to severe TBI treated in the prehospital setting with 2 dosing regimens of TXA:

    • Clinical outcomes: ICH progression, DRS at discharge and 6 months, GOS-E at discharge, 28-day survival, frequency of neurosurgical interventions, and ventilator-free, ICU-free, and hospital-free days.
    • Safety outcomes: Development of seizures, cerebral ischemic events, myocardial infarction, deep venous thrombosis, and pulmonary thromboembolism.
    • Mechanistic outcomes: Alterations in fibrinolysis based on fibrinolytic pathway mediators and degree of clot lysis based on TEG.

    A multi-center double-blind randomized controlled trial with 3 treatment arms:

    • Bolus/maintenance: 1 gram IV TXA bolus in the prehospital setting followed by a 1 gram IV maintenance infusion initiated on hospital arrival and infused over 8 hours.
    • Bolus only: 2 grams IV TXA bolus in the prehospital setting followed by a placebo maintenance infusion initiated on hospital arrival and infused over 8 hours.
    • Placebo: Placebo IV bolus in the prehospital setting followed by a placebo maintenance infusion initiated on hospital arrival and infused over 8 hours.
  • Risk of Ventral Hernia after Open Abdomen Rochester, Minn.

    The purpose of this study is to compare the rate of developing a ventral hernia after a damage control laparotomy between patients who had Botox induced abdominal muscle paralysis and those that did not.

  • Small Bowel Obstruction Anatomic Severity Score Rochester, Minn.

    The purpose of this study is to determine the concordance of the American Association for the Surgery of Trauma – Small Bowel Obstruction (AAST-SBO) scoring system with mortality and to determine if adding a comorbidity and physiologic scoring system improves the concordance.

  • The Feasibility of a Warm, Fresh, Whole Blood Transfusion Program Rochester, Minn. The objective of the study is to identify a population of healthy blood donors that would be willing to donate blood within short notice (less than 6 hours) and to identify perceived barriers to donation.
  • The Functional Outcomes and Recovery After Trauma Emergencies (FORTE) Study (FORTE) Rochester, Minn.

    The purpose of this study is to develop and implement a multi-institutional, longitudinal database to identify functional and patient-centered outcomes after trauma in the United States.

  • Validation of a novel algorithm to interpret compensatory reserve and hemoglobin monitoring device input Rochester, Minn.

    The aim of this study is to evaluate the effectiveness of this novel algorithm that makes use of data from existing FDA approved non-invasive monitoring devices.

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