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Clinical Studies

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  • Unraveling Immunological Dysregulation and Genetic Factors in Psoriatic Arthritis (PsA) Rochester, Minn.

    The purpose of this study is to evaluate the phenotype, stability, functionality, transcriptome and TCR repertoire of peripheral vs synovial Tregs from PsA patients and HCs. Additionally, to establish a HIS mouse model of PsA to evaluate autoimmune responses against the joint and tendon tissues, and to evaluate the potential of CD2-KO Tregs in protecting human joint and tendon cells from autoreactive immune responses in vivo.

Closed for Enrollment

  • Unraveling Immunological Dysregulation and Genetic Factors in Psoriatic Arthritis (PsA) Scottsdale/Phoenix, Ariz.

    The purpose of this study is to evaluate the phenotype, stability, functionality, transcriptome and TCR repertoire of peripheral vs synovial Tregs from PsA patients and HCs. Additionally, to establish a HIS mouse model of PsA to evaluate autoimmune responses against the joint and tendon tissues, and to evaluate the potential of CD2-KO Tregs in protecting human joint and tendon cells from autoreactive immune responses in vivo.
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