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  • Clinical Validation of 5-hydroxyindoleacetic Acid in Plasma and Urine Rochester, Minn.

    This study aims to clinically validate two new liquid chromatography-tandem mass spectrometry (LC-MS/MS) assays for 5-hydroxyindole-3-acetic acid (5-HIAA) in (1) human plasma, and (2) randomly collected urine specimens, and to determine true plasma and random urine 5HIAA levels in those confirmed in or suspected of having carcinoid syndrome (CS); thus establishing a disease range to compare to previously-established normal ranges.