Closed for Enrollment

• Amitriptyline and Topiramate in the Prevention of Childhood Migraine Rochester, Minn.

  The purpose of this research study is to test two medicines for migraine prevention in children and adolescents. The investigators want to see if amitriptyline and/or topiramate are better than placebo (sugar pill) in reducing headache frequency in children and adolescents ages 8 to 17 with migraines. At this time, there are no FDA approved medicines approved in the US for the prevention treatment of migraine headaches in children and adolescents.

• BOTOX (Botulinum Toxin Type A) Purified Neuortoxin Complex as Headache Prophylaxis in Adolecents (Children 12 to < 18 years of age) with Chronic Migraine Rochester, Minn.

  To evaluate the efficacy and safety of Botulinum Toxin Type A versus placebo (normal saline) as headache prophylaxis in adolescents (children 12 to 17) with chronic migraine.