Faculty

Brendan C. Lanpher, M.D.

Clinical Studies

A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Efficacy and Safety Study of Pitolisant Followed by an Open-Label Extension in Patients with Prader-Willi Syndrome Rochester, Minn.
The purpose of this study is to evaluate the impact of pitolisant on Excessive daytime sleepiness in patients with Prader-Willi syndrome.
Clinical and Genetic Evaluation of Patients With Undiagnosed Disorders Through the Undiagnosed Diseases Network Rochester, Minn.
The purpose of this study is to establish a national network added to and building upon the National Institutes of Health Undiagnosed Diseases Program (NIH UDP).

The specific aims of the UDN are to improve the level of diagnosis and care for patients with undiagnosed diseases through the development of common and site-specific protocols designed by an enlarged community of investigators, and to facilitate research into the etiology of undiagnosed diseases, by collecting and sharing standardized, high-quality clinical and laboratory data including genotyping, phenotyping, and documentation of environmental exposures.

An open-label, single-center, single-participant study of an experimental antisense oligonucleotide treatment for a patient with LMNB1 mutation associated Autosomal Dominant Leukodystrophy (ADLD) Rochester, Minn.
The purpose of this study is to determine the efficacy and safety of an experimental drug, an anti-sense oligonucleotide (ASO) called nL-LMNB1-001. Currently there is no standard therapy for LMNB1 mutation associated Autosomal Dominant Leukodystrophy (ADLD), a fatal central nervous system white matter demyelinating disorder.
Investigation of Hyperammonemia in Patients Status Post Roux-en-Y Gastric Bypass Surgery Rochester, Minn.
The purpose of this study is to determine plasma levels of Peptide YY (PYY), ghrelin, ammonia, and amino acids prior to and after Roux-en-Y gastric bypass surgery.