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A Multicenter, Open-label Study to Evaluate the Safety and Diagnostic Efficacy of Mangoral in Patients With Known or Suspected Focal Liver Lesions and Severe Renal Impairment (SPARKLE)
Jacksonville, Fla.
The overall purpose of this study is to evaluate the safety and diagnostic effectiveness of Mangoral in liver MRI in patients with known or suspected focal liver lesions and severe renal impairment. The diagnostic efficacy of Mangoral will be assessed in terms of visualization of detected focal liver lesions in combined MRI (CMRI: combined Mangoral-enhanced and unenhanced MRI) compared to unenhanced MRI.
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Correlation of Hepatic MR Elastography with Histopathology and/or Abdominal MRI in Patients with Chronic Liver Disease and Malignancy: A Prospective Study
Scottsdale/Phoenix, Ariz.
The purpose of this study is to compare the accuracy of non-invasive MRE (Magnetic Resonance Elastography) with the results of liver biopsy and/or MRI (Magnetic Resonance Imaging).
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Determinants of Diabetic Nephropathy in American Indians
Scottsdale/Phoenix, Ariz.
The purpose of this study is to examine the evolution of diabetic kindey injury over an extended period in a group of subjects who previously completed a clinical trial which assessed the ability of losartan to protect the kidney from injury in early diabetic kidney disease. We will also explore the relationship between diabetic kidney disease and other diabetes complications, including neuropathy and retinopathy.
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Fatty Liver Disease and Its Determinants in American Indians of the Strong Heart Study (SHS)
Scottsdale/Phoenix, Ariz.
This research study will evaluate magnetic resonance (MR) studies (imaging and elastography) to assess methods to estimate liver fat and fibrosis among American Indians (AI) with high rates of obesity, insulin resistance and variable alcohol (EtOH) use. MR examinations in this study are obtained in the same way as routine images are obtained on MR scanners, using radio waves and magnetic fields.
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Hybrid C-11 Choline and Multiparametric Pelvic PET/MR: Correlation of Imaging Biomarkers with Histopathology in Intermediate to High Risk Primary Prostate Cancer
Scottsdale/Phoenix, Ariz.
The purpose of this study is to establish and validate imaging, surgery, and pathology protocols for C11 Choline PET/MR and pathology correlation in radical prostatectomy planning.
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Multi-Parametric Magnetic Resonance Technique for Measuring Ionization Track Density in Human Liver Treated with High Energy External Radiotherapy Beam
Scottsdale/Phoenix, Ariz.
The purpose of this study is to evaluate the effects of radiation on normal liver tissue. This will help us develop MRI-based dose range monitoring techniques for liver Stereotactic Body Radio Therapy.
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