Faculty

Piero Rinaldo, M.D., Ph.D.

Clinical Studies

Clinical Validation of 5-hydroxyindoleacetic Acid in Plasma and Urine Rochester, Minn.
This study aims to clinically validate two new liquid chromatography-tandem mass spectrometry (LC-MS/MS) assays for 5-hydroxyindole-3-acetic acid (5-HIAA) in (1) human plasma, and (2) randomly collected urine specimens, and to determine true plasma and random urine 5HIAA levels in those confirmed in or suspected of having carcinoid syndrome (CS); thus establishing a disease range to compare to previously-established normal ranges.

Establishment of Disease Ranges of Selected Markers and Ratios for the Detection of OTC Deficiency and CPS Deficiency using Newborn Blood Spots Rochester, Minn.
The purpose of this study is to obtain and analyze existing newborn screening data from previously identified patients with a confirmed diagnosis of a urea cycle disorder (UCD) (when all necessary analytes were measured by the state laboratories) OR collect and analyze dried blood spots from newborn screening cards of previously identified patients with a confirmed diagnosis of a urea cycle disorder (UCD).