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The primary objective of this application is to establish the feasibility of widespread clinical use of advanced MRS technology for early AD diagnosis in a strategic alliance between MR physicists at the UMN and physician scientists at Mayo Clinic.
The purpose of this study is to demonstrate whether 4 years of menopausal hormone treatment (MHT) with estrogen initiated at, or shortly after, menopause retards progression of carotidintimal/medial thickness (CIMT) as determined by B-mode ultrasound, and the development of complex atheroslerotic lesions in the coronary aretries as indicated by measurements of vascular calcium, with computerized x-ray tomography.
The purpose of this study is to assess the effects of menopausal hormone therapy and normal aging on cognitive performance and imaging markers of brain structure in women approximately thirteen years after enrolling in the KEEPS trial. KEEPS participants were randomized to oral or transdermal estrogen treatments or placebo within three years of menopause. This is a follow up study of these women approximately thirteen years after randomization (9 years after study completion.) No treatments are given as part of this study; any current hormonal treatments are by choice and prescribed by the participant's personal physician.
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