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  • B-Cells Contribute to the Development of Lung Fibrosis in a Subset of Patients with Diffuse Interstitial Lung Diseases Rochester, Minn.

    The purpose of this study is to investigate the possibility that B lymphocytes (a kind of white blood cell ) may be contributing to the development of fibrosis in the lungs. This study will examine if B lymphocytes, isolated from  blood, can induce the stimulation of fibroblasts. Fibroblasts are cells that are responsible for the formation of scarring in the lungs. Specific markers found in the surface of B lymphocytes will also be investigated to see if it can be identified why these cells may induce the development of fibrosis.

     

  • Immune Cell Activation of Healthy Human Subjects Rochester, Minn.

    The purpose of this research study is to establish a pool of healthy donors who will regularly participate in our research studies of human immunity. The studies in our laboratory investigate the role of human blood cells in immunity to fungal disease and lung fibrosis. Most of our studies require blood that is freshly drawn. Thus, we propose to draw blood on an as needed, ongoing basis.

  • Understanding Pulmonary Fibrosis using iPSC Technology Rochester, Minn.

    The purpose of this study is to obtain lung fibroblasts (a cell type that participates in fibrosis of the lung) to study then in the laboratory to identify why they are different from fibroblast from normal individuals.

    Once these cells are obtained, they will be grown in culture plates in the laboratory to be developed into many different cell types. These cells will be evaluated for their function in the laboratory, and to determine if they can continue to grow/function. Any cells that are left will be frozen for use in future experiments.

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