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Development of a Peptide-Based SARS-CoV-2 Candidate Vaccine (SARS-CoV-2)
Rochester, Minn.
The purpose of this study is to identify SARS-CoV-2 peptides capable of being processed and presented by antigen presenting cells during viral infection, to test peptides for biologic/immunologic relevance in PBMCs from recovered COVID-19+ cases, and to perform in vivo infection studies in mice (ACE2 x HLA A2 transgenic) using individual peptide and/or peptide combinations with and without adjuvants to identify the optimal protective potential of the identified peptide/peptides against wild virus challenge.
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