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Evaluation Of Pirfenidone As A Novel Therapeutic Strategy Against Recurrent Acute Pancreatitis.
Rochester, MN
The purpose fo this study will evaluate the safety, tolerability and early efficacy of pirenidone in patients with recurrent acute pancreatitis.
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PROSPECTIVE EVALUATION OF CHRONIC PANCREATITIS FOR EPIDEMIOLOGIC AND TRANSLATIONAL STUDIES (THE PROCEED STUDY) (PROCEED)
Rochester, MN
The objectives of this study are to establish a model longitudinal research cohort of adult patients for the study of Chronic Pancreatitis (CP), its complications, to estimate the risk of progression from suspected to definite CP, and the risk of new-onset diabetes or exocrine insufficiency in definite CP, and study how the risks are influenced by patient characteristics and conditions, to test the predictive capability of candidate biomarkers for diagnosis and prognosis of CP, to develop a framework for conducting biomarker, genetic, and mechanistic studies using clinical information and the biorepository developed as part of the longitudinal research cohort.
Closed for Enrollment
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Development and Feasibility Testing of An Internet-based Pain Self-management Program for Persons with Acute Recurrent and Chronic Pancreatitis Pain (The IMPACT study) (IMPACT)
Rochester, MN
The purpose of this study are 1) to refine an existing internet-delivered pain self-management program for use in adult chronic pancreatitis (CP) patients, and 2) to pilot its use in this patient population, generating preliminary feasibility and acceptability data to inform design of a subsequent large randomized controlled trial.
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Evaluation Of Pirfenidone As A Therapy In Patients With Predicted Moderate To Severe Acute Pancreatitis
Rochester, MN
The goal of the current pilot clinical trial is to evaluate the safety and tolerability of pirfenidone in patients with predicted moderately severe and severe acute pancreatitis. Pirfenidone is currently approved by FDA for the treatment of idiopathic pulmonary fibrosis. Now, over 5 years of data has accumulated demonstrating safety of its use in humans. The investigators' preclinical data suggest that pirfenidone is very effective in reducing the severity of acute pancreatitis in animal models. Following are the objectives of the proposed clinical trial: Primary Objective: -To evaluate the safety and tolerability of pirfenidone, compared to placebo, in patients predicted to have moderately severe or severe AP. -To evaluate the efficacy of pirfenidone in reducing the laboratory markers of inflammation and improving patient reported outcome measures. Secondary Objective: - To evaluate the efficacy of pirfenidone in reducing the severity of acute pancreatitis, as measured by well-defined endpoints.
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Magnetic Resonance Imaging as a Non- Invasive Method for the Assessment of Pancreatic Fibrosis (MINIMAP)
Rochester, MN
The purpose of this study is to evaluate magnetic resonance imaging (MRI) as a non-invasive imaging method to detect chronic pancreatitis (CP) and quantify pancreatic fibrosis.
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Phase 1/2 Trial of Indomethacin in Chronic Pancreatitis (The PAIR Trial)
Rochester, MN
The purpose of this study is to assess the physiologic effect of orally administered indomethacin (IN) on pancreatic juice PGE2 concentrations in patients with chronic pancreatitis (CP).
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Safety, Tolerability And Dose Limiting Toxicity Of Lacosamide In Patients With Painful Chronic Pancreatitis. (STTEPP)
Rochester, MN
The purpose of this study is to determine the safety, tolerability and dose-limiting toxicity of adding lacosamide to opioid therapy for the treatment of abdominal pain due to chronic pancreatitis (CP). Also, to assess the feasibility of performance of a pilot study adding lacosamide to opioid therapy in these subjects.
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Salivary Biomarkers of Chronic Pancreatitis: Pilot Study
Rochester, MN
The purpose of this study is to discover new ways of diagnosing chronic pancreatitis (CP) earlier in the course of the disease by studying molecules found in saliva.
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