Closed for Enrollment

• Examining the Preliminary Efficacy, Feasibility, and Acceptability of an Exercise Intervention on Frailty After Kidney Transplantation Rochester, Minn.

  The purpose of this study is to conduct a clinical trial examining the preliminary effectiveness, feasibility, and acceptability of an exercise intervention on frailty after kidney transplantation (KT).

• Senescence, Frailty, and Mesenchymal Stem Cell Functionality in Chronic Kidney Disease: Effect of Senolytic Agents Rochester, Minn.

  To compare the effect of senolytic drugs on cellular senescence, physical ability or frailty, and adipose tissue-derived MSC functionality in patients with chronic kidney disease.
  
  Primary Objectives:
  To assess the efficacy of a single 3-day treatment regimen with dasatinib and quercetin (senolytic drugs) on clearing senescent adipose-derived MSC in patients with CKD.
  
  To assess the efficacy of a single 3-day treatment regimen with dasatinib and quercetin (senolytic drugs) on improving adipose-derived MSC functionality in patients with CKD.
  
  Secondary Objective:
  To assess the short-term effect of a single 3-day treatment regimen with dasatinib and quercetin (senolytic drugs) on frailty index score in patients with CKD.
  
  To assess the short-term effect of a single 3-day treatment regimen with dasatinib and quercetin (senolytic drugs) on kidney function in patients with CKD.
  
  To assess the safety and tolerability of a single 3-day treatment regimen with dasatinib 100 mg daily and quercetin 1000 mg total daily in subjects with CKD.