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Closed for Enrollment
Evaluation of neuroendocrine differentiation as a potential mechanism of tumor recurrence following radiotherapy
This is a pilot study to test a hypothesis that a greater increase in serum chromogranin A (CgA) after a definitive radiotherapy (RT) with or without androgen deprivation therapy (ADT) is associated with a higher risk of prostate cancer recurrence after RT. Serum CgA level is measured before the start of RT and/or the start of neoadjuvant ADT for patients undergoing a definitive RT with or without ADT. CgA is also measured at various pre-defined post-RT time points. The study will analyze the followings: 1. Change in CgA level at various pre-defined post-RT time points from the baseline, 2. Correlation between the extent of post-therapy CgA change and Gleason score of malignancy, 3. Correlation between the extent of post-therapy CgA change and treatment outcome.
Closed for Enrollment
Optimization of Gene Expression Biomarkers and Bioassay for Radiation Biodosimetry using Human Blood Irradiation Experiments to Study Gene Expression Changes following Radiation Exposure: Collaboration with ASU-BARDA
The goal of this study is to investigate gene expression changes in blood (biomarkers) after a person is exposed to radiation. The gene biomarkers identified and selected from data collected in this study will allow healthcare personnel to estimate the level of radiation exposure in an individual as demonstrated by the changes in the levels of these biomarkers. In case of a radiological event, it is beneficial to determine the amount of radiation absorbed, together with other diagnostic tools, to provide important information for medical treatment of the victim. This would be extremely helpful for emergency planning and response. Data from this study may be used to help the development of an experimental diagnostic system that measures gene expression changes rapidly from a small sample of blood.
Prospective Evaluation of Hypofractionation Proton Beam Therapy with Concurrent Treatment of the Prostate and Pelvic Nodes for Clinically Localized, Intermediate or High Risk Prostate Cancer
The purpose of this study is to evaluate the safety and effectiveness of a moderate hypofractionation regimen of proton beam therapy with same time treatment of the prostate, seminal vesicles, and the regional pelvic nodes for patients who have clinically localized, high risk or unfavorable intermediate risk prostate cancer.