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A Randomized, Phase 2/3, Open-Label Study To Investigate The Efficacy And Safety Of RP2 In Combination With Nivolumab Versus Ipilimumab In Combination With Nivolumab In Immune Checkpoint Inhibitor-Naïve Adult Patients With Metastatic Uveal Melanoma
Jacksonville, FL
Rochester, MN
The purpose of this study is to compare the effect of RP2 + nivolumab relative to ipilimumab + nivolumab on overall survival (OS) and to compare the effect of RP2 + nivolumab relative to ipilimumab + nivolumab on progression free survival (PFS).
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A Randomized, Phase 3, Open-label Study Of Neoadjuvant Darovasertib In Subjects With Primary Non-metastatic Uveal Melanoma (OptimUM-10)
Scottsdale/Phoenix, AZ
Jacksonville, FL
Rochester, MN
This is a Phase 3, randomized, multi-center, open-label study of neoadjuvant darovasertib in subjects with primary non-metastatic uveal melanoma (OptimUM-10)
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Phase 2/3 Randomized Study Of Tebentafusp As Monotherapy And In Combination With Pembrolizumab Versus Investigator's Choice In HLA-A*02:01-positive Participants With Previously Treated Advanced Melanoma (TEBE-AM)
Scottsdale/Phoenix, AZ
Jacksonville, FL
Rochester, MN
The purpose of this study is to evaluate the effectiveness and safety of tebentafusp-based regimens tebentafusp monotherapy and in combination with anti-PD1) vs investigator choice (including clinical trials of investigational agents, salvage therapy per local standard of care (SoC), best supportive care (BSC)) on protocol survivor follow up) in patients with advanced non-ocular melanoma.
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A Phase 1, Open-label, Multicenter, Dose Escalation Study Evaluating The Safety, Tolerability, Pharmacokinetics And Efficacy Of KQB168 As Monotherapy And In Combination With Pembrolizumab In Participants With Advanced Solid Malignancies
Scottsdale/Phoenix, AZ
Jacksonville, FL
Rochester, MN
The goal of this clinical trial is to learn if KQB168 works to treat advanced solid tumor cancer in adults. It will also learn about the safety of KQB168. The main questions it aims to answer are:
* What is the safe dose of KQB168 by itself or in combination with pembrolizumab?
* Does KQB168 alone or in combination with pembrolizumab decrease the size of the tumor?
* What happens to KQB168 in the body?
Participants will:
* Take KQB168 daily, alone or in combination with pembrolizumab
* Visit the clinic about 8 times in the first 8 weeks, and then once every 3 weeks after that
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