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Clinical Studies


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  • Arthroscopic Partial Meniscectomy in OA: A 12-Year Follow-Up (MeTeOR) Rochester, Minn.

    The goals of this continuation of MeTeOR are to determine: a) whether the greater structural damage observed at five years in subjects treated with APM persists over 12 years; and b) whether structural changes observed in the first five years are associated with worse pain and function and greater TKR utilization at 12 years. We propose the following aims:

    1. Conduct a 12-year follow-up visit of MeTeOR subjects to characterize the extent of cartilage damage over 12 years and identify factors associated with OA progression. MeTeOR participants will complete questionnaires and performance tests and undergo MRI and radiographs 12 years after randomization. Our analyses of cartilage damage will account for clinical and demographic features at baseline and prognostically salient events occurring over follow-up. We hypothesize that subjects with greater baseline levels of cartilage damage and those treated with APM will experience greater cartilage damage over 12 years.
    2. Assess whether the extent of structural progression over the first five years post-treatment in persons with OA and meniscal tear predicts worse clinical outcomes at 12 years. We hypothesize that more rapid progression over the initial five years will be predictive of greater pain, worse functional status, worse performance test results, and higher use of TKR at 12 years, independent of clinical and demographic features ascertained over the first five years. We will also assess the extent of progression in cartilage damage that is predictive of a clinically meaningful difference in KOOS Pain scores.
  • Surgical Timing and Rehabilitation (STaR) Trial for Multiple Ligament Knee Injuries (MLKIs): A Multicenter Integrated Clinical Trial (STAR) Rochester, Minn.

    The overall objective of this project is to investigate the effects of timing of surgery (early vs. delayed) and timing of post-op rehabilitation (early vs. delayed) for the treatment of military personnel and civilians that have sustained a Multiple Ligament Knee Injury (MLKI).