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  • Changes in Gut Microbiota after Endoscopic Procedures for the Treatment of Obesity Scottsdale/Phoenix, Ariz., Rochester, Minn.

    The purpose of this study is to learn more about the effects of similar weight loss through caloric restriction, gastric reduction, and bypass of the proximal small intestines on gut microbiota and compare them to changes in the microbiome of obese subjects undergoing sham procedures and life-style modification.

  • Ex Vivo Evaluation of Total Bacterial Count in Adult Human Duodenal Fluid Scottsdale/Phoenix, Ariz.

    The purpose of this study is to develope a rapid lab test for counting total bacteria in human intestinal fluid collected by aspiration from the duodenal section of the small intestine.

  • Weight Loss in Parkinson's Disease and the Potential Role of Small Bowel Bacterial Overgrowth Scottsdale/Phoenix, Ariz.

    The potential role of Small bowel bacterial overgrowth (SBBO) in weight loss occurring in patients with PD has not previously been examined. Our hypothesis is that SBBO is an important contributor to the development of weight loss in individuals with Parkinson's disease. The investigators propose to 1) examine the role of SBBO in weight loss occurring in patients with PD and 2) determine the response to its treatment with a poorly absorbed antibiotic. The investigators propose to perform a prospective, observational case-control study with an open-label therapeutic component. Cases will be defined as those PD patients who've experienced significant weight loss while Controls will be defined as those PD patients who have not experienced significant weight loss.