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Clinical Studies

Closed for Enrollment

  • PRIME-AIR study An Anesthesia-Centered Bundle to Reduce Postoperative Pulmonary Complications (PRIME-AIR) Rochester, Minn.

    PRIME-AIR is a multicenter, prospective, controlled open-label parallel-group clinical trial to test the effect of an individualized perioperative anesthesia-centered bundle on the number and severity of postoperative pulmonary complications (PPCs). Eligible patients will be adults undergoing major open abdominal surgery with intermediate or high risk for developing PPCs. These represent a large population of abdominal surgery patients sustaining the relevance and generalizability of the study. We plan to study a total of 750 adult patients undergoing abdominal surgery with general anesthesia and mechanical ventilation. Patients will receive the intervention perioperatively and will be followed by hospital visits and a daily phone call until discharged home or until 7 days after surgery. Phone calls or hospital visits will also be done immediately after postoperative days 7, 30 and 90 to determine additional complications.

  • Protective Ventilation with Higher versus Lower PEEP During General Anethesia for Surgery in Obese Patients - The PROBESE Randomized Controlled Trial (PROBESE) Rochester, Minn.

    The purpose of this study is to compare a ventilation strategy using higher levels of positive end expiratory pressure and recruitment maneuvers to one using lower levels of positive end expiratory pressure without recruitment maneuvers in obese patients at an intermediate-to-high risk for post surgery respiratory complications.

     

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