Mark A. Frye, M.D.

The purpose of this study is to test whether there are statistically significant differences in spoken language present on an intra- and inter-individual level between mania and euthymic stages in patients with Bipolar I Disorder as measured by the Young Mania Rating Scale (YMRS)  along with clinical markers of disease including hours of sleep per night.  

The purpose of this research is to develop a questionnaire that includes the important items related to how patients living with depression describe their daily experience and how it relates to feelings of wellness.

The purpose of this research is to understand the different ways in which patients and health care providers currently work together to figure out how to treat and manage bipolar depression. This process is called shared decision making. We aim to assess the characteristics and extent of shared decision making that has occurred during your clinical encounter.

The purpose of this study is to create a a large database and bio-repository of clinical information and blood samples from participants with BD type- I (BD-I), type- II (BD-II) and schizoaffective disorder, bipolar type (SCZ-BD) and extending an invitation for some of our previous patients who participated in the Mayo Clinic Bipolar Biobank from 2009 to 2018 and MoStGEN Biobank from 2021 to 2025 to have them return for a second new blood draw for this new protocol.

The purpose of this study is to identify and characterize mitochondrial profiles associated with clinical outcomes, including depressive symptom severity, cognitive function, and treatment response, in bipolar depression.

 

The FLAME Study is a 16-week clinical trial to study treatment with lamotrigine or fluoxetine in bipolar I, II and bipolar schizoaffective depressed adults. The purpose of the trial is to have a better understanding of whether individuals with a particular gene type and other inherited biological markers will have a good response to fluoxetine or lamotrigine, or alternatively, would be more likely to have side effects to this medication.

This study uses an MRI scan called an MR Spectroscopy to measure brain chemicals before and after treatment with lamotrigine or fluoxetine in patients with bipolar depression. This better understanding of therapy impact on brain function may help individualize future treatment for bipolar depression.

This study will compare glutamate and other neurometabolites measured by proton magnetic resonance spectroscopy (1H-MRS) in bipolar I and II patients currently depressed with age-matched healthy controls. The study will also compare 1H-MRS of bipolar I and II patients before and after taking a 12-week course of lamotrigine. This study requires 8 visits over a 12 week period. These visits need to occur at Mayo Clinic in Rochester, MN.

The purpose of this study is to see if varenicline will decrease alcohol consumption and increase alcohol abstinence rates when given to alcoholic patients for both alcohol and smoking cesation treatment.

The overall goal of this investigator-initiated trial is to evaluate the treatment outcome of depression utilizing platform algorithm products that can allow rapid identification of pharmacokinetic (PK) and/or pharmacodynamic (PD) genomic variation. This new technology may have the potential to optimize treatment selection by improving response, minimizing unfavorable adverse events / side effects and increasing treatment adherence.

The purpose of this study is to assess the effectiveness and safety of MYDAYIS® as an augmentation agent for bipolar depression.

The purpose of this study is to explore whether Medibio’s system can provide objective measures of response to standard medication treatment for unipolar depression and bipolar depression, and to see if the system can tell these two conditions apart.

Medibio’s system uses software to analyse a person’s heart rate, activity, and posture to provide objective measures of a person’s autonomic nervous system, sleep, and other daily patterns.

The purpose of this study is to evaluate the clinical and neurocognitive correlates of COVID-19 in patients with bipolar disorder (BD). 

The purpose of this study is to:

1. To evaluate whether the genotypic and phenotypic results for a single subject are the same among companies offering pharmacogenomics testing.

2. To evaluate the consistency among company generated lists of medications stratified into groups regarding usage for a single subject (i.e., “use as directed,” “use with caution,” or “use with increased caution and with more frequent monitoring”).

The purpose of this study is to assess the feasibility and acceptability of passive data collection with a smartphone in depressed patients and investigate how passive data gathered via technology platforms can generate transdiagnostic digital phenotypes that potentially inform the assessment and/or treatment outcome of major mood disorders. This study aims to assess self-reported, behavioral, cognitive, and physiological data gathered from smartphones and smart watches as compared to gold standard clinical measured in treatment seeking depressed patients.

The purpose of this study is to determine if genetic analysis of participants treated with ECT will identify gene loci associated with severe mood disorders, including major depressive disorder (MDD) or bipolar disorder (BPD), at genome-wide significance in comparison to participants with milder mood disorders.

This protocol will investigate the neurobiological underpinnings of alcohol craving in recently detoxified alcoholic drinkers utilizing novel functional brain imaging. This clinical magnetic resonance spectroscopy (MRS) study will investigate whether glutamate and other brain metabolites correlate to measures of alcohol craving severity.

The purpose of this biobank is to develop a research resource for bipolar disorder. Patients, and close genetic relatives, will provide samples of blood, complete interviews, complete health questionnaires, and allow access to medical records. Participants will also agree to be followed into the future by linking to medical records, along with occasional follow-up health surveys or collection of additional biologic specimens. The biobank serves as a source for researchers instead of having to look for volunteers for each new project.

The goal of this proposed study is to examine the genetic signature of the validated proteomic signature (model) based on a panel of serum proteomic markers that discriminates different mood disorders.

The purpose of this study is to create a larger database and bio-repository to examine pharmacogenomics in patients with BD type I and type II treated with mood stabilizing anticonvulsants, atypical antipsychotics and antidepressant medications. 

The purpose of this research study is to compare the antidepressant effect of lithium versus placebo in adults receiving ketamine. Lithium is available commercially for depression; ketamine is available commercially and can help the symptoms of depression; however, it has not been approved by the U.S. Food and Drug Administration (FDA) for this use. The FDA has allowed the use of this drug in this research study.