A Study to Evaluate Presbycusis and Presbyvestibulopathy and Risk for Mild Cognitive Impairment and Dementia


About this study

The purpose of this study is to examine baseline vestibular and balance problems with cognitive function and diagnosis as compareed to previously studied associations of Presbycusis with cognition function.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Adults, 50+ years old and older. There is no upper age limit for the subject if they are an independent, self-sufficient person, in good general health, and are able to pass a routine, standard evaluation.
  • An equal cohort of male and female subjects.

To be enrolled as presbycusis patient, the Vaden et al. 2017, one of the criteria needed to be:

  • fulfilled;
  • Older-normal presbycusis phenotype: (audiograms with thresholds in low to midfrequency less than 20 dB hearing level and slightly increased thresholds for higher frequencies);
  • Metabolic (audiograms with mild, flat hearing losses at lower frequencies and gradually sloping hearing loss at higher frequencies) with hearing thresholds no more than 50dB;
  • Sensory (steeply sloping 50- to 70-dB threshold shifts that predominantly affect higher frequencies;
  • Metabolic plus sensory (combined metabolic declines and sensory damage);
  • Functional presbycusis measured by speech audiometry and subjective hearing difficulties;
  • No vestibular symptoms or signs.

To be enrolled as presbyvestibulopathy patient, the Bárány Society criteria needed to be fulfilled (Strupp et al., 2017) with no objective functional presbycusis.

To be enrolled as presbycusis and presbyvestibulopathy patient, the Bárány Society criteria needed to be fulfilled with an objective and/or functional presbycusis.

Exclusion Criteria:

  • Patients who have been previously diagnosed with depression or cognitive deficits.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Jacksonville, Fla.

Mayo Clinic principal investigator

David Zapala, Ph.D.

Contact us for the latest status

Contact information:

David Zapala Ph.D.



More information


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