Clinical Trials

Inclusion Criteria:

• Diagnosis of Postural Orthostatic Tachycardia Syndrome.
• Patients between the ages of 13-18.
• Current or former athlete, defined as an individual who has participated in organized sport and expresses a desire to return to organized sport.
• Cleared by the managing physician to begin an intensive exercise program.

Exclusion Criteria:

• Medically unfit to begin an intensive exercise program:
  • As determined by the inability to complete ADLs due to the severity of symptoms, and/or the inability to exercise > 3 days weekly due to the severity of symptoms.
• Active and uncontrolled Mast Cell Activation Syndrome:
  • As diagnosed by referring physician
  • Current statement by WHO states diagnostic criteria includes 2 or greater symptoms for 2 or more different systems, chronic and aberrant reactivity to identifiable triggers, and symptoms cannot reasonably be accounted for by another illness.
• Uncontrolled post-exertional malaise:
  • Screened using DePaul Symptom Questionnaire – Post Exertional Malaise (DSQ-PEM)
  • Scores greater than 2,2 (frequency and severity) classify as uncontrolled PEM

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 10/15/2024. Questions regarding updates should be directed to the study team contact.