Research

The Precision Neurotherapeutics Innovation Program is engaged in exploring a variety of solutions to improve treatment options for neurological diseases. Research focus area include:

• Mathematical modeling. Individualized modeling is adopted as a contemporary paradigm, balancing mathematical modeling with clinical translational research. Such a paradigm leverages precision medicine in individualizing the treatment of cancers and other pathologies.
• Device innovation. The research team uses virtual reality, augmented reality, 3D printing and finite element analysis software to create the next generation of neurosurgical devices. Through collaborations with local educational institutions, medical centers and private industry players, this program has become a center for designing, testing and launching future devices with applications in the neurosurgical field and beyond.
• Simulation-based learning. This project is a hub for innovation in the educational realm, creating the simulation teaching modalities needed to train future Mayo Clinic neurosurgeons. Simulation modalities, along with their associated curricula, will enhance the educational experiences of medical students, neurosurgical residents and practicing consultants.
• Physical and computational patient-specific simulation. This project uses computerized tomography (CT) and magnetic resonance imaging (MRI) scans to create a 3D model of each person's unique anatomy and pathology. The 3D-printed versions of these models allow neurosurgeons to plan their approach and practice procedures in a simulated setting before patients' surgeries. This process improves operative efficiency and safety and leads to better outcomes.
• Medical application of augmented and mixed reality. This project is one of the first in the world to study the feasibility of applying augmented and mixed reality in neurosurgical and other medical fields.
• Imaging modalities innovation. This project uses the latest imaging modalities to diagnose and treat people with intracranial and spinal pathologies more precisely and to instruct clinicians and surgeons in the best approaches for treatment and surgical removal.
• Robotics in the neurosurgical field. The Precision Neurotherapeutics Innovation Program is using robotic brain-computer interface devices by collaborating with bioengineers at Arizona State University. This partnership sets the stage for clinical trials and validation studies to enhance the quality of life of people with disabilities.