The Clinical Immunology and Immunotherapeutics Program at Mayo Clinic is dedicated to translational research on immune-mediated diseases, with the goal of expanding the scope of clinical immunology from classical areas — including autoimmunity, allergy, transplantation and cancer immunotherapy — to emerging fields such as immunosenescence, microbial therapeutics and molecular immunology.

The program promotes collaborative research activities within the Department of Immunology, the Division of General Internal Medicine and across Mayo Clinic, along with other institutions and industry partners. The faculty comprises a diverse group of investigators who have immunology-related interests within their specialties.

The program's specific objectives to advance immunology research include:

  • Promoting research in clinical immunology by providing research support for clinical immunology projects
  • Bringing together investigators with common interests, facilitating the exchange of ideas and resources, and promoting synergy among investigators
  • Providing resources and training grant opportunities for junior or new faculty members at Mayo Clinic who want to conduct research in the immunological sciences
  • Fostering collaborative projects with other programs within the Department of Internal Medicine — particularly programs focused on autoimmunity, cancer immunology, mucosal immunity, aging and immunovirology
  • Seeking opportunities to work together with other Mayo Clinic departments, including but not limited to the Department of Immunology and the Department of Laboratory Medicine and Pathology

The Federation of Clinical Immunology Societies (FOCIS)

FOCIS comprises 61 member societies and represents approximately 65,000 physician scientists.

It provides:

  • A scientific forum to foster the cross-disciplinary approaches required to understand and treat immune-based diseases as the discipline of clinical immunology evolves
  • A better understanding of the shared pathophysiological underpinnings of clinical immunology and the new therapeutic approaches suggested by these novel relationships, including the increasingly widespread use of biologics in therapy
  • A forum for education of trainees, physicians, patients and the public in the discipline of clinical immunology
  • Advocacy in public policy issues

As part of its mission, FOCIS has created Centers of Excellence worldwide to accelerate multidisciplinary scientific and clinical innovation and education.

Mayo Clinic is one of the institutions designated as a FOCIS Center of Excellence in the United States. With this designation, Mayo Clinic shares a national and international leadership role and responsibility to promote clinical immunology as an expanding area of laboratory diagnosis, clinical practice, research and education.

Khashayarsha Khazaie, Ph.D., and Amir A. Sadighi Akha, M.D., D.Phil., serve as the director and associate director of Mayo Clinic's FOCIS Center of Excellence, respectively.


The Clinical Immunology and Immunotherapeutics Program is affiliated with other Mayo Clinic research areas, including: