Location

Rochester, Minnesota

Contact

Malhi.Harmeet@mayo.edu Clinical Profile

Summary

Harmeet Malhi, MBBS, studies mechanisms of liver injury and inflammation in the context of nonalcoholic fatty liver disease. The cellular pathways of interest to Dr. Malhi's laboratory are endoplasmic reticulum stress and macrophage activation and their role in mediating liver injury and inflammation in nonalcoholic fatty liver disease.

Focus areas

  • MicroRNAs in fatty liver disease. Dr. Malhi has identified microRNAs regulated by palmitate, a lipotoxic free fatty acid, and is characterizing the pathways regulated by these microRNAs.
  • C/EBP homologous protein. Dr. Malhi is using complementary in vitro and genetic knockout models to study the endoplasmic reticulum stress-induced transcription factor C/EBP homologous protein in macrophage activation and cell death.
  • Lipotoxic macrophage activation. Dr. Malhi is investigating the role of mediators of endoplasmic reticulum stress in lipotoxic macrophage activation.

Significance to patient care

The goal of Dr. Malhi's laboratory is to provide understanding of the role of macrophages in fatty liver disease. The expectation is to define the molecular mechanisms of macrophage recruitment and activation in the liver such that novel biomarkers or druggable targets might be identified, thereby improving diagnosis and treatment of nonalcoholic fatty liver disease.

Recent Publications

See my publications

Professional Details

Academic Rank

  1. Assistant Professor of Medicine

Education

  1. Fellow - Advanced Hepatology Mayo School of Graduate Medical Education, Mayo Clinic College of Medicine
  2. Fellow Clinician-Investigator Program, Programs in Rochester, Mayo School of Graduate Medical Education, Mayo Clinic College of Medicine
  3. Resident Mayo School of Graduate Medical Education, Mayo Clinic College of Medicine
  4. Research Associate Albert Einstein College of Medicine
  5. MB BS University College of Medical Sciences, University of Delhi
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BIO-00027918

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