Publications

  1. Liu Y, Verma V, Malhi H, Gores GJ, Kamath PS, Sanyal AJ, Chalasani N, Gao B, Shah VH. Lipopolysaccharide downregulates macrophage-derived IL-22 to attenuate alcohol induced hepatocyte cell death. Am J Physiol Cell Physiol 2017 Jun 21; ajpcell.00005.2017 Epub 2017 June 21
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  2. Camilleri M, Malhi H, Acosta A. Gastrointestinal Complications of Obesity. Gastroenterology 2017 May; 152 (7):1656-1670 Epub 2017 Feb 10
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  3. Mauer AS, Hirsova P, Maiers JL, Shah VH, Malhi H. Inhibition of sphingosine 1-phosphate signaling ameliorates murine nonalcoholic steatohepatitis. Am J Physiol Gastrointest Liver Physiol 2017 Mar 01; 312 (3):G300-G313 Epub 2016 Dec 30
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  4. Maiers JL, Kostallari E, Mushref M, deAssuncao TM, Li H, Jalan-Sakrikar N, Huebert RC, Cao S, Malhi H, Shah VH. The unfolded protein response mediates fibrogenesis and collagen I secretion through regulating TANGO1 in mice. Hepatology 2017 Mar; 65 (3):983-998 Epub 2016 Dec 31
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  5. Yin M, Glaser KJ, Manduca A, Mounajjed T, Malhi H, Simonetto DA, Wang R, Yang L, Mao SA, Glorioso JM, Elgilani FM, Ward CJ, Harris PC, Nyberg SL, Shah VH, Ehman RL. Distinguishing between Hepatic Inflammation and Fibrosis with MR Elastography. Radiology 2017 Jan 27; 160622 [Epub ahead of print]
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  6. Hirsova P, Ibrahim SH, Verma VK, Morton LA, Shah VH, LaRusso NF, Gores GJ, Malhi H. Extracellular vesicles in liver pathobiology: Small particles with big impact. Hepatology 2016 Dec; 64 (6):2219-2233 Epub 2016 Oct 20
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  7. Hirsova P, Ibrahim SH, Gores GJ, Malhi H. Lipotoxic lethal and sublethal stress signaling in hepatocytes: relevance to NASH pathogenesis. J Lipid Res 2016 Oct; 57 (10):1758-1770 Epub 2016 Apr 05
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  8. Ibrahim SH, Hirsova P, Malhi H, Gores GJ. Animal Models of Nonalcoholic Steatohepatitis: Eat, Delete, and Inflame. Dig Dis Sci 2016 May; 61 (5):1325-36 Epub 2015 Dec 01
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  9. Hirsova P, Ibrahim SH, Krishnan A, Verma VK, Bronk SF, Werneburg NW, Charlton MR, Shah VH, Malhi H, Gores GJ. Lipid-Induced Signaling Causes Release of Inflammatory Extracellular Vesicles From Hepatocytes. Gastroenterology 2016 Apr; 150 (4):956-67 Epub 2016 Jan 05
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  10. Malhi H, Allen AM, Watt KD. Nonalcoholic fatty liver: optimizing pretransplant selection and posttransplant care to maximize survival. Curr Opin Organ Transplant 2016 Apr; 21 (2):99-106
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  11. Ibrahim SH, Hirsova P, Tomita K, Bronk SF, Werneburg NW, Harrison SA, Goodfellow VS, Malhi H, Gores GJ. Mixed lineage kinase 3 mediates release of C-X-C motif ligand 10-bearing chemotactic extracellular vesicles from lipotoxic hepatocytes. Hepatology 2016 Mar; 63 (3):731-44 Epub 2015 Dec 11
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  12. Verma VK, Li H, Wang R, Hirsova P, Mushref M, Liu Y, Cao S, Contreras PC, Malhi H, Kamath PS, Gores GJ, Shah VH. Alcohol stimulates macrophage activation through caspase-dependent hepatocyte derived release of CD40L containing extracellular vesicles. J Hepatol 2016 Mar; 64 (3):651-60 Epub 2015 Nov 26
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  13. Kakazu E, Mauer AS, Yin M, Malhi H. Hepatocytes release ceramide-enriched pro-inflammatory extracellular vesicles in an IRE1alpha-dependent manner. J Lipid Res 2016 Feb; 57 (2):233-45 Epub 2015 Nov 30
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  14. Hirsova P, Ibrabim SH, Gores GJ, Malhi H. Thematic review series: Lipotoxicity: many roads to cell dysfunction and cell death lipotoxic lethal and sublethal stress signaling in hepatocytes: Relevance to NASH pathogenesis Journal of Lipid Research 2016; 57 (10):1758-70
  15. Idrissova L, Malhi H, Werneburg NW, LeBrasseur NK, Bronk SF, Fingas C, Tchkonia T, Pirtskhalava T, White TA, Stout MB, Hirsova P, Krishnan A, Liedtke C, Trautwein C, Finnberg N, El-Deiry WS, Kirkland JL, Gores GJ. TRAIL receptor deletion in mice suppresses the inflammation of nutrient excess. J Hepatol 2015 May; 62 (5):1156-63 Epub 2014 Nov 28
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  16. Hirsova P, Ibrahim SH, Bronk SF, Krishnan A, Werneburg NW, Verma VK, Shah VH, Malhi H, Gores GJ. Lipotoxicity Induces Release of Proinflammatory Extracellular Vesicles from Hepatocytes. Gastroenterology. 2015.
  17. Hassler JR, Scheuner DL, Bai Y, Sartor M, Cavacoli J, Malhi H, Song B, Back SH, George JS, Davis C, Wu P, Ferris SP, Wang S, Han J, Liu M, Arvan P, Kaufman RJ. ß-Cell Specific Deletion of IRE1α Causes a Diabetic Phenotype Due to Faulty Insulin Synthesis and Maturation. PLoS Genetics under review. 2015.
  18. Hassler JR, Scheuner DL, Wang S, Han J, Kodali VK, Li P, Nguyen J, George JS, Davis C, Wu SP, Bai Y, Sartor M, Cavalcoli J, Malhi H, Baudouin G, Zhang Y, Yates JR III, Itkin-Ansari P, Volkmann N, Kaufman RJ. The IRE1 alpha/XBP1s pathway is essential for the glucose response and protection of beta cells. PLoS Biol. 2015; 13(10):e1002277.
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  19. Malhi H. MICRORNAs IN ER STRESS: DIVERGENT ROLES IN CELL FATE DECISIONS. Curr Pathobiol Rep 2014 Sep; 2 (3):117-122
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  20. Miyamoto Y, Mauer AS, Kumar S, Mott JL, Malhi H. Mmu-miR-615-3p regulates lipoapoptosis by inhibiting C/EBP homologous protein. PLoS One 2014; 9 (10):e109637 Epub 2014 Oct 14
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  21. Malhi H, Kropp EM, Clavo VF, Kobrossi CR, Han J, Mauer AS, Yong J, Kaufman RJ. CEBP homologous protein-induced macrophage apoptosis protects mice from steatohepatitis. J Biol Chem 2013 Jun 28; 288 (26):18624-42 Epub 2013 May 17
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  22. Han J, Murthy R, Wood B, Song B, Wang S, Sun B, Malhi H, Kaufman RJ. ER stress signalling through eIF2alpha and CHOP, but not IRE1alpha, attenuates adipogenesis in mice. Diabetologia 2013 Apr; 56 (4):911-24 Epub 2013 Jan 12
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  23. Guicciardi ME, Malhi H, Mott JL, Gores GJ. Apoptosis and necrosis in the liver. Compr Physiol 2013 Apr; 3 (2):977-1010
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  24. Fisher JE, McKenzie TJ, Lillegard JB, Yu Y, Juskewitch JE, Nedredal GI, Brunn GJ, Yi ES, Malhi H, Smyrk TC, Nyberg SL. Role of Kupffer cells and toll-like receptor 4 in acetaminophen-induced acute liver failure. J Surg Res 2013 Mar; 180 (1):147-55 Epub 2012 Dec 20
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  25. Malhi H, Kaufman RJ. Endoplasmic reticulum stress in liver disease. J Hepatol 2011 Apr; 54 (4):795-809 Epub 2010 Nov 13
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  26. Malhi H, Guicciardi ME, Gores GJ. Hepatocyte death: a clear and present danger. Physiol Rev 2010 Jul; 90 (3):1165-94
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  27. Malhi H, Gores GJ. Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease. Semin Liver Dis 2008 Nov; 28 (4):360-9 Epub 2008 Oct 27
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  28. Malhi H, Gores GJ. Cellular and molecular mechanisms of liver injury. Gastroenterology 2008 May; 134 (6):1641-54
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  29. Malhi H, Joseph B, Schilsky ML, Gupta S. Development of cell therapy strategies to overcome copper toxicity in the LEC rat model of Wilson disease. Regen Med 2008 Mar; 3 (2):165-73
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  30. Malhi H, Gores GJ. Molelcular Mechanisms of Lipotoxicity in Non Alcoholic Fatty Liver Disease. Seminars in Liver disease. 2008; 28(4):360-9.
  31. Barreyro FJ, Kobayashi S, Bronk SF, Werneburg NW, Malhi H, Gores GJ. Transcriptional regulation of Bim by FoxO3A mediates hepatocyte lipoapoptosis. J Biol Chem 2007 Sep 14; 282 (37):27141-54 Epub 2007 July 11
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  32. Malhi H, Barreyro FJ, Isomoto H, Bronk SF, Gores GJ. Free fatty acids sensitise hepatocytes to TRAIL mediated cytotoxicity. Gut 2007 Aug; 56 (8):1124-31 Epub 2007 Apr 30
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  33. Malhi H, Gores GJ. Cholangiocarcinoma: modern advances in understanding a deadly old disease. J Hepatol 2006 Dec; 45 (6):856-67 Epub 2006 Sept 25
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  34. Malhi H, Gores GJ. TRAIL resistance results in cancer progression: a TRAIL to perdition? Oncogene 2006 Nov 30; 25 (56):7333-5 Epub 2006 June 19
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  35. Malhi H, Gores GJ. Review article: the modern diagnosis and therapy of cholangiocarcinoma. Aliment Pharmacol Ther 2006 May 01; 23 (9):1287-96
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  36. Malhi H, Bronk SF, Werneburg NW, Gores GJ. Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis. J Biol Chem 2006 Apr 28; 281 (17):12093-101 Epub 2006 Feb 27
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  37. Malhi H, Gores GJ, Lemasters JJ. Apoptosis and necrosis in the liver: a tale of two deaths? Hepatology 2006 Feb; 43 (2 Suppl 1):S31-44
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  38. Malhi H, Atac B, Daly AK, Gupta S. Warfarin and celecoxib interaction in the setting of cytochrome P450 (CYP2C9) polymorphism with bleeding complication. Postgrad Med J 2004 Feb; 80 (940):107-9
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  39. Giri RK, Malhi H, Joseph B, Kandimalla J, Gupta S. Metal-catalyzed oxidation of extracellular matrix components perturbs hepatocyte survival with activation of intracellular signaling pathways. Exp Cell Res 2003 Dec 10; 291 (2):451-62
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  40. Joseph B, Bhargava KK, Malhi H, Schilsky ML, Jain D, Palestro CJ, Gupta S. Sestamibi is a substrate for MDR1 and MDR2 P-glycoprotein genes. Eur J Nucl Med Mol Imaging 2003 Jul; 30 (7):1024-31 Epub 2003 Jan 21
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  41. Wege H, Le HT, Chui MS, Liu L, Wu J, Giri R, Malhi H, Sappal BS, Kumaran V, Gupta S, Zern MA. Telomerase reconstitution immortalizes human fetal hepatocytes without disrupting their differentiation potential. Gastroenterology 2003 Feb; 124 (2):432-44
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  42. Joseph B, Malhi H, Bhargava KK, Palestro CJ, McCuskey RS, Gupta S. Kupffer cells participate in early clearance of syngeneic hepatocytes transplanted in the rat liver. Gastroenterology 2002 Nov; 123 (5):1677-85
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  43. Malhi H, Gorla GR, Irani AN, Annamaneni P, Gupta S. Cell transplantation after oxidative hepatic preconditioning with radiation and ischemia-reperfusion leads to extensive liver repopulation. Proc Natl Acad Sci U S A 2002 Oct 01; 99 (20):13114-9 Epub 2002 Sept 20
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  44. Cho JJ, Malhi H, Wang R, Joseph B, Ludlow JW, Susick R, Gupta S. Enzymatically labeled chromosomal probes for in situ identification of human cells in xenogeneic transplant models. Nat Med 2002 Sep; 8 (9):1033-6 Epub 2002 Aug 19
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  45. Malhi H, Annamaneni P, Slehria S, Joseph B, Bhargava KK, Palestro CJ, Novikoff PM, Gupta S. Cyclophosphamide disrupts hepatic sinusoidal endothelium and improves transplanted cell engraftment in rat liver. Hepatology 2002 Jul; 36 (1):112-21
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  46. Malhi H, Irani AN, Gagandeep S, Gupta S. Isolation of human progenitor liver epithelial cells with extensive replication capacity and differentiation into mature hepatocytes. J Cell Sci 2002 Jul 01; 115 (Pt 13):2679-88
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  47. Malhi H, Irani AN, Volenberg I, Schilsky ML, Gupta S. Early cell transplantation in LEC rats modeling Wilson's disease eliminates hepatic copper with reversal of liver disease. Gastroenterology 2002 Feb; 122 (2):438-47
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  48. Malhi H, Bhargava KK, Afriyie MO, Volenberg I, Schilsky ML, Palestro CJ, Gupta S. 99mTc-mebrofenin scintigraphy for evaluating liver disease in a rat model of Wilson's disease. J Nucl Med 2002 Feb; 43 (2):246-52
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  49. Gorla GR, Malhi H, Gupta S. Polyploidy associated with oxidative injury attenuates proliferative potential of cells. J Cell Sci 2001 Aug; 114 (Pt 16):2943-51
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  50. Irani AN, Malhi H, Slehria S, Gorla GR, Volenberg I, Schilsky ML, Gupta S. Correction of liver disease following transplantation of normal rat hepatocytes into Long-Evans Cinnamon rats modeling Wilson's disease. Mol Ther 2001 Mar; 3 (3):302-9
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  51. Malhi H, Gupta S. Hepatocyte transplantation: new horizons and challenges. J Hepatobiliary Pancreat Surg 2001; 8 (1):40-50
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  52. Gupta S, Malhi H, Gorla GR. Re-Engineering the liver with natural biomaterials. Yonsei Med J 2000 Dec; 41 (6):814-24
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  53. Gupta S, Rajvanshi P, Malhi H, Slehria S, Sokhi RP, Vasa SR, Dabeva M, Shafritz DA, Kerr. Cell transplantation causes loss of gap junctions and activates GGT expression permanently in host liver. Am J Physiol Gastrointest Liver Physiol 2000 Oct; 279 (4):G815-26
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  54. Malhi H, Irani AN, Rajvanshi P, Suadicani SO, Spray DC, McDonald TV, Gupta S. KATP channels regulate mitogenically induced proliferation in primary rat hepatocytes and human liver cell lines. Implications for liver growth control and potential therapeutic targeting. J Biol Chem 2000 Aug 25; 275 (34):26050-7
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  55. Zahler MH, Irani A, Malhi H, Reutens AT, Albanese C, Bouzahzah B, Joyce D, Gupta S, Pestell RG. The application of a lentiviral vector for gene transfer in fetal human hepatocytes. J Gene Med 2000 May-Jun; 2 (3):186-93
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  56. Gupta S, Malhi H, Gagandeep S, Novikoff P. Liver repopulation with hepatocyte transplantation: new avenues for gene and cell therapy. J Gene Med 1999 Nov-Dec; 1 (6):386-92
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