Keith L. Knutson. Ph.D., is currently an Associate Professor in the Department of Immunology at the Mayo Clinic.
He received his Ph.D. from the University of Georgia in Physiology and Pharmacology in 1995 and completed two post-doctoral fellowships in immunology: One at the University of British Columbia; and the other at the University of Washington. He was a 2004 recipient of a Howard Temin Award from the National Cancer Institute.
Dr. Knutson's current interests and research focuses on the immunology and immunotherapy of breast and ovarian cancers, both the basic immunobiology and clinical translation, including clinical trials.
The laboratory conducts research on cancer vaccines focuses on augmenting CD4 helper T cell immunity using peptide epitopes. These vaccine strategies are aimed at preventing the patients from relapsing after optimal conventional therapies. Adoptive T cell therapy is also being examined, a strategy that involves infusing high numbers of T cells into patients with active bulky malignancy.
Studies in the lab important to adoptive T cell therapy include methods of T cell expansion and in vitro generation of memory T cells.
Lastly, research is also aimed at understanding how tumors evade the immune system. A number of different mechanisms and several areas of immune escape are being investigated including cellular reprogramming (e.g., epithelial to mesenchymal transition); and recruitment of regulatory T cells and myeloid derived suppressor cells into the tumor microenvironment.
In addition to his research, Dr. Knutson participates in and chairs several study sections; is Co-director, Mayo Clinic Immune Monitoring Core; and Director, Ovarian Cancer Immunotherapy Program at Mayo Clinic.
See my publications
- Associate Professor of Immunology
- Postdoctoral Fellowship Division of Medical Oncology, University of Washington
- Postdoctoral Fellowship Department of Medicine, University of British Columbia
- PhD - Pharmacology University of Georgia
- BS - Microbiology University of Washington, Seattle
- AA - Business Administration South Seattle Community College