Location

Rochester, Minnesota

Contact

khosla.sundeep@mayo.edu Clinical Profile

SUMMARY

The research of Sundeep Khosla, M.D., focuses on the mechanisms of age-related bone loss, sex steroid regulation of bone metabolism and the detrimental effects of diabetes mellitus on bone. Dr. Khosla's research group is examining how fundamental aging mechanisms in bone lead to increased skeletal fragility. In addition, Dr. Khosla also uses a number of genetically engineered disease models to define how estrogen regulates the skeleton. In clinical studies, Dr. Khosla is examining the adverse effects of type 2 diabetes mellitus on bone structure and material properties, which may explain the increase in fracture risk in this population.

Focus areas

  • Mechanisms of age-related bone loss
  • Sex steroid action on bone
  • Effects of diabetes mellitus on bone

Significance to patient care

Dr. Khosla's work has the potential to significantly impact how patients with osteoporosis are diagnosed and treated. Specifically, his work on defining the pathways that lead to bone loss with aging and estrogen deficiency may identify new molecular targets for drugs to reverse osteoporosis. Additionally, Dr. Khosla's studies have identified skeletal fragility as an important complication of diabetes mellitus, leading to greater attention to reducing fracture risk in these patients.

Professional highlights

  • Council member, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), 2014-present
  • Director, Center for Clinical and Translational Science, Mayo Clinic, 2013-present
  • Recipient, William F. Neuman Award for Outstanding Scientific Contributions, American Society for Bone and Mineral Research (ASBMR), 2012
  • President, ASBMR, 2010-2011
  • Recipient, Outstanding Clinical Investigator Award, Endocrine Society, 2010
  • Recipient, Dr. Francis Chucker and Nathan Landow Research Professor and Mayo Foundation Distinguished Investigator, 2009
  • Member, National Advisory Council on Aging, 2007-2010
  • Elected, Association of American Physicians, 2007
  • Recipient, Frederic C. Bartter Award for clinical investigation in bone diseases, ASBMR, 2006
  • Chair, Skeletal Biology Development and Disease Study Section, National Institute of Health, 2004-2006
  • Elected, American Society for Clinical Investigation, 2003

PUBLICATIONS

See my publications

PROFESSIONAL DETAILS

Primary Appointment

  1. Endocrinology

Joint Appointment

  1. Physiology and Biomedical Engineering

Academic Rank

  1. Professor of Physiology
  2. Professor of Medicine

EDUCATION

  1. Clinical/Research Fellowship - Clinical and Research Fellowship in Endocrinology Massachusetts General Hospital
  2. Resident - Resident in Medicine Massachusetts General Hospital
  3. MD - MIT Program in Health Sciences and Technology Harvard Medical School
  4. AB - Chemistry and Physics Harvard College

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BIO-00078126

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