The research of Sundeep Khosla, M.D., focuses on the pathophysiology of bone loss in women and men. This involves epidemiological, clinical, animal and basic studies.
Dr. Khosla is particularly interested in how declining sex steroid levels in aging women and men are related to bone loss. These studies are complemented by animal studies, which use genetically engineered mice, as well as studies in basic bone cell biology that examine sex steroid action on bone cells at different stages of differentiation.
In addition, Dr. Khosla's laboratory is involved in studies on osteoprogenitor and mesenchymal stem cell differentiation.
- Mechanisms of bone loss in women and in men
- Sex steroid action on bone
- Osteoprogenitor and stem cell biology
Significance to patient care
Dr. Khosla's work has the potential to significantly impact how patients with osteoporosis are diagnosed and treated. Using new imaging approaches, his group is attempting to identify patients at increased risk of fracture before currently available tools are able to do so.
In addition, his work on defining the pathways that lead to bone loss with estrogen deficiency and aging may identify new molecular targets for drugs to reverse osteoporosis.
- Director and principal investigator, Mayo Clinic Center for Clinical and Translational Science (CCaTS), 2013-present
- Dean for Clinical and Translational Science, Mayo Clinic, 2013-present
- President, American Society for Bone and Mineral Research, 2010-2011
- Member, National Advisory Council on Aging, National Institute on Aging, 2007-2010
- Clinical Investigator Award and Lecture, The Endocrine Society, 2010
- Election to the Association of American Physicians, 2007
- Frederic C. Bartter Award (for clinical investigation in bone diseases), American Society for Bone and Mineral Research, 2006