The research interests of Joseph P. Grande, M.D., Ph.D., center on understating and developing treatments for chronic renal disease, with a current focus on hypertension and diabetes. Dr. Grande's laboratory employs a variety of experimental and translational approaches to understand the role of inflammation on the development of chronic renal disease.
- Renovascular hypertension. Dr. Grande's laboratory studies the role of T cells and macrophages in the development of renal atrophy in the stenotic kidney and compensatory enlargement of the contralateral kidney in unilateral renovascular hypertension.
- Diabetes. Dr. Grande's research team has recently developed a murine model of diabetes that develops severe renal disease. Recent studies have focused on establishing basic mechanisms of renal disease progression in this model and on preclinical studies to determine efficacy of therapies that target renal inflammation in diabetic renal disease.
- Chronic allograft dysfunction. With better treatments for acute renal transplant rejection, chronic dysfunction is now the leading cause of graft failure. Dr. Grande has served as study pathologist for a multicenter study to define basic patterns of chronic renal allograft dysfunction.
Significance to patient care
Diabetes and hypertension are two of the leading causes of end-stage renal disease in the United States. Dr. Grande's work on the role of inflammation on the development and progression of renal injury will lead to the identification of novel therapeutic targets to arrest the progression of chronic renal disease in patients with these common disorders.
- Regular member, Pathobiology of Kidney Disease study section, National Institutes of Health, 2008-2011