Rochester, Minnesota


MFrye@mayo.edu Clinical Profile


Dr. Frye received his medical degree from the University of Minnesota and completed his psychiatric training at the UCLA Neuropsychiatric Institute. He completed a subsequent research fellowship in the Biological Psychiatry Branch at the National Institute of Mental Health (NIMH) in Bethesda, Maryland. While at NIMH, his area of research was focusing on the neurobiology of depression and bipolar disorder. Formerly the Director of the UCLA Bipolar Disorder Research Program (1998-2006), he is now the Director of the Mayo Mood Clinic and Research Program. His clinical interests are in bipolar disorder, depression, and alcoholism with a research focus on genomics, brain imaging, and neuroendocrinology of mood disorders and alcoholism. RESEARCH GRANTS AWARDED Ongoing Research Support National Institute on Alcohol Abuse and Alcoholism (NIAAA) P20 The Mayo Clinic Center for Individualized Treatment of Alcohol Dependence (CITA)Magnetic Resonance Spectroscopy in Humans: An Acamprosate Probe Study National Institute of Mental Health RO1MH079261 1H-MR Spectroscopy of Bipolar Depression Before & After Lamotrigine Treatment SC Johnson Foundation Genomics of Addiction Mayo Clinic with a Generous Gift from the Marriott Family. Mayo Clinic Individualized Medicine Biobank for Bipolar Disorder Frye, Biernacka (Co-PIs) Mayo Clinic CR Program Deep Brain Stimulation and Mood in Parkinson's Disease: A Prospective Follow-up Study Mayo Clinic Small Grants Award Adjunctive Varenicline for Smoking Cessation in Bipolar Depressed Patients: An Open-label 12-week Feasibility Trial


See my publications


Primary Appointment

  1. Psychiatry

Academic Rank

  1. Professor of Psychiatry


  1. Research Fellowship National Institute of Mental Health, Biological Psychiatry Branch
  2. Resident - General Psychiatry UCLA Neuropsychiatric Institute, UCLA School of Medicine
  3. MD University of Minnesota School of Medicine
  4. Diplom - Diplome de Langue L'Alliance Francaise, Paris
  5. BA - Biology Luther College

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