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Cytogenetic Technology Program

Cancer

Cytogenetic Technology Program

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Cytogenetic Technology Overview

Chromosomes

Cancer

Congenital Syndromes

Treatment Regimen

Response to Therapy

Miscarriages

New Therapies

FISH Basics

Gene Level

Microdeletions

Interphase Nuclei

Types of FISH Probes

Complete Picture

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Mission Statement

t(9;22) in CML

Translocation between chromosomes 9 and 22 found in Chronic Myeloid Leukemia (CML). This translocation brings two different genes (Abelson oncogene/ABL and Breakpoint Cluster Region/BCR) together. The new gene combination codes for a hybrid protein that alters the cell's regulatory mechanisms and causes cancer.

t(15;17) in APL

Translocation between chromosomes 15 and 17 found in Acute Promyelocytic Leukemia (APL). This translocation brings two different genes (Promyelocytic Leukemia/PML and Retinoic Acid Receptor Alpha/RARa) together. The new gene combination codes for a hybrid protein that alters the cell's regulatory mechanisms and causes cancer.


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