|
The Molecular Neuroscience Ph.D. program at Mayo is a transdepartmental training program that unites approximately 60 basic neuroscientists and clinician-scientists as faculty. Members of our training faculty have wide-ranging expertise and truly multidisciplinary research interests.
A sample of the ongoing research in our program includes:
- advanced techniques to non-invasively visualize the central nervous system
- antiviral immunity in the central nervous system
- application of novel bioscaffolding materials to spinal cord repair and regeneration
- biophysical properties of amyloid fibrils in Alzheimer disease
- calcium pump defects in hereditary deafness
- cell biology of neuron function in the enteric nervous system
- drug development in schizophrenia and depression
- dysfunctional neuronal lipid storage and processing in Niemann Pick type C disease
- dysregulation of small GTPases and axonal trafficking in amyotrophic lateral sclerosis
- dysregulation of Sonic hedgehog signaling in CNS tumor formation
- genetic basis of demyelination and remyelination in multiple sclerosis
- genetic suppression of neuronal hyperexcitabilty and epilepsy
- high-resolution nuclear magnetic resonance spectroscopy of neural systems
- immune-mediated axonal injury in the demyelinated CNS
- immunogenetics of experimental autoimmune encephalitis
- inflammatory basis of seizure induction during viral encephalitis
- magnetic resonance imaging and spectroscopy in small animal models of neural injury
- mechanisms of respiratory control
- mechanisms underlying axon guidance and regeneration
- mitochondrial dysfunction in Freidreich ataxia
- modulation of adenosine transporters to control alcohol addiction
- molecular mechanisms of paraneoplastic autoimmunity against CNS antigens
- molecular mechanisms of sleep dysregulation
- neurogenetics of brain tumors
- neurogenetics of movement disorders
- neuropathologic basis of neurodegenerative diseases such as Parkinson disease
- neurotransmitter receptor structure:function analysis
- neurotrophin-mediated modulation of neuromuscular transmission
- noninvasive imaging of the CNS via magnetic resonance elastography
- novel imaging tools for the detection of plaques in Alzheimer disease
- pharmacogenetics of neurotransmitter modulating drugs
- proteolytic cascades in multiple sclerosis and spinal cord injury pathogenesis and repair
- rational design of cocaine-hydrolyzing cholinesterases
- receptor trafficking and internalization in neurons
- small molecule library screening for Alzheimer disease drug leads
- therapeutic strategies to promote remyelination in multiple sclerosis
|
