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Services and Assays

Services

The Metabolomics Core:

  • Develops stable isotope methodologies and makes them available to clinical investigators across various disciplines
  • Provides advice and expertise in the application of stable isotope-labeled tracer techniques
  • Offers measurement of metabolic profiles, both in terms of metabolite identification and quantification

Assays

Assays available in the core and those under development include:

AssayMedium
Mass spectrometry (gases)
CO2Expired air
Doubly labeled waterUrine
DeuteriumUrine
DeuteriumPlasma
Gas chromatography mass spectrometry (GC/MS)
[6,6-d2]glucosePlasma
[1-13C]glucosePlasma
[6,6-d2]glucose plus [1-13C]glucose panelPlasma
[13C2]oxalateUrine
[d2]d-riboseCells
[d5]glycerolPlasma
[13C3]glycerolPlasma
Liquid chromatography with tandem mass spectrometry (LC-MS/MS)
[ring-13C6]phenylalaninePlasma
[ring-13C6]tyrosinePlasma
[15N]tyrosinePlasma
[d5]phenylalaninePlasma
[ring-13C6]phenylalanineTissue fluid
[d5]phenylalanineTissue fluid
[d4]cortisol plus cortisone panelPlasma
[4-13C]cortisol plus [d7]cortisone panelPlasma
[ring-13C6]phenylalanineGel spots
[d5]phenylalanineGel spots
[U-13C]palmitatePlasma
[U-13C]oleatePlasma
Ceramide plus metabolitesPlasma or tissue
Free fatty acid (FFA) panelPlasma
[U-13C]palmitoyl carnitineMuscle
[13C4]palmitoyl carnitineMuscle
[U-13C]oleoyl carnitineMuscle
8-oxo-dGDNA
Large-scale metabolites profilingPlasma or tissue
Diazepam plus metabolites panelMedia
Gas chromatography combustion isotope ratio mass spectrometry (GC-C-IR/MS)
[U-13C]palmitatePlasma
[U-13C]oleatePlasma
Under development
Metabolites identificationPlasma or tissue
IsoprostanesPlasma
Citric acid fluxTissue
Diacylglycerol (DAG)Plasma or tissue
Glutamic acid fluxPlasma
Arachidonic acid plus metabolitesPlasma or tissue
  • ART202263