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Essentials of Clinical and Translational Science (ECaTS)

Essentials of Clinical and Translational Science (ECaTS) provides medical professionals with foundational knowledge of research terminology, research methods and processes, clinical epidemiology, and biomedical statistics.

Upon completion, learners understand clinical and translational science, basic terminology and methodological concepts in epidemiology from a clinical perspective, and basic statistical methods used in a variety of clinical study designs. The program prepares learners to critically review medical literature such as scholarly publications.

Program highlights

  • Anytime, anywhere learning.
  • Self-directed and self-paced (asynchronous).
  • Aligns with Accreditation Council for Graduate Medical Education (ACGME) practice-based learning and improvement competency (IV.A.5.b and IV.A.5.c) (ACGME Common Program Requirements).
  • Includes content assessed on the United States Medical Licensing Examination (USMLE) Step 1 exam under the competency of "Practice-based Learning and Improvement," which requires understanding and application of the principles of biostatistics and epidemiology(USMLE Step 1 Content Outline and Specifications).
  • Approximately 55 hours of course work.
  • Learners have up to six months to complete the program, and the content is accessible for one year after admission.
  • A certificate of completion is granted upon successful completion of the program.


A nonrefundable program fee of $500 per participant, paid via departmental PAU or credit card, is charged upon successful registration.


All Mayo Clinic employees are eligible to take this program.


Mayo Clinic employees: Register here

**Disclaimer: The content and program do not fulfill prerequisite requirements for Mayo Graduate School graduate credit courses or transfer to the CCaTS Postdoctoral Master's Degree Program or Postdoctoral Diploma Program.


  • ECaTS includes approximately 55 hours of education.
  • Participants have up to six months to complete the program.
  • The content is accessible for one year after admission.
  • A score of 80 percent or higher is required on each knowledge check to move to the next module.
  • A certificate of completion is granted upon successful completion of the program.

The ECaTS curriculum provides foundational concepts of research methods that inform students how to critically review the medical literature.

Fundamentals of Clinical and Translational Science (FunCaTS)


  • Identify and describe the clinical and translational science process
  • Describe the impact clinical and translational science has on clinical practice, including the social and ethical context
  • Explain clinical and translational science methodologies

Introduction to Clinical Epidemiology


  • Describe the differences between observational and experimental study designs
  • Discuss the differences between accuracy and precision and their implications in epidemiologic studies
  • Compare and contrast the basic epidemiologic study designs and their relative strengths and weaknesses
  • Discuss the concepts of confounding and bias, and how they might influence inference in epidemiologic studies
  • Interpret the standard measurements used for evaluating diagnostic tests, discuss how these are applied in the population context, and how screening programs are evaluated

Biostatistics in Clinical Research


  • Develop the ability to interpret the results of a variety of basic statistical techniques, including both exploratory and inferential methods
  • Develop the ability to recognize, define and differentiate fundamental concepts of statistics, such as variability, distribution, association, causation, sampling, experimentation, confidence and significance
  • Develop tools to determine appropriate statistical methods for different types of data and study designs
  • Develop a critical perspective with which to assess and defend statistical arguments, such as those in scholarly publications

Supplemental curriculum

JMP software online modules, part of the CCaTS' Statistics and Informatics Software, supplement the ECaTS Program.

Looking for additional online professional development modules? Visit the CCaTS Workforce Development.


The Education Contacts page contains a listing of team members who can assist you with questions.

  • Feb 22, 2018
  • ART500673