Aptamers in Multiple Sclerosis Research
Structure of myelin oligodendrocyte glycoprotein, an MS autoantigen
The Maher Lab collaborates with a team of multiple sclerosis (MS) experts at Mayo Clinic to explore possible new tools for imaging MS lesions and for promoting cellular remyelination in response to damage.
Dr. Maher's team and collaborators are asking whether small folded DNA molecules (aptamers) can be generated with binding affinity for important cell-surface molecules on neurons and MS lesions. The biological properties of such aptamers can then be assessed in comparison with conventional protein antibodies.
Dr. Maher's lab is exploring new possible multiple sclerosis treatment options, including DNA aptamers to induce neuron remyelination in a mouse model.
Mayo Clinic researchers discover means to reverse multiple sclerosis symptoms in mice