Musculoskeletal System Research

Musculoskeletal system research in the Mayo Clinic Motion Analysis Laboratory includes the following focus areas:

Direct anterior approach and miniposterior approach total hip arthroplasty

The Motion Analysis Lab is conducting a randomized clinical trial comparing two different surgical approaches for total hip arthroplasty: the direct anterior approach and the miniposterior approach. Researchers are measuring activity and subjective survey outcomes before and after surgery to compare the different surgical techniques.

Hip range of motion during activities of daily living

The lab's research in this area aims to quantify hip joint range of motion during activities of daily living. Researchers are studying three participant groups: adults with hip osteoarthritis, adults who have had a unilateral hip replacement and a control group of adults with no lower extremity joint disease.

Results will define the degree to which current joint replacements provide adequate range of motion relative to a healthy control group. This data will be used to direct future implant device design.

Comparative effectiveness between microprocessor knees and nonmicroprocessor knees

Dr. Kaufman's lab is evaluating the comparative effectiveness of subjects using two types of prosthesis designs in older adults with above-knee amputations: microprocessor knees and nonmicroprocessor knees. This study examines activity levels, patient satisfaction and falls.

Prospective trial comparing functional outcomes after kinematic and mechanical alignment in total knee arthroplasty

Researchers in the Motion Analysis Lab are comparing function and subjective outcomes of two different total knee arthroplasty alignment methods: kinematic and mechanical. The lab hypothesizes that performing total knee arthroplasty utilizing kinematic alignment has superior outcomes compared with the classic mechanical alignment for total knee replacement.

Development of a microsensor for intramuscular pressure (IMP)

The lab's research in this area is aimed at developing a fiber-optic microsensor to measure IMP, determining the relationship between IMP and muscle tension under dynamic conditions for normal muscle in an animal model, developing a mathematical model of IMP, and conducting in vivo human experiments to evaluate the neurophysiology of IMP.

Effect of treatment on activity and muscle function in pediatric patients with scoliosis

The Motion Analysis Lab's goal in this focus area is to understand the effect of the treatment of scoliosis on patients' lives, beyond the radiographic findings.

The lab hypothesizes that after surgical or bracing scoliosis treatment, patients are significantly less active in the free-living environment, are subject to atrophy and undergo physical changes of their spinal musculature. Researchers are working to quantify the effect of scoliosis treatment on patients' lives to develop interventions during scoliosis treatment that will optimize patients' functional outcomes.