The Genomic Hepatobiology Laboratory aims to elucidate the genetic predisposition and the genetic-environmental interaction that contribute to the development of chronic cholestatic liver diseases, namely primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC).

Over the past decade Konstantinos N. Lazaridis, M.D., and his colleagues have created and maintained the largest research resource of PBC and PSC probands, including a family registry in the U.S. This resource is linked to a repository of genomic DNA and cell lines, as well as serum and plasma biospecimens that are used for studying and developing novel therapies.

Dr. Lazaridis hopes his team's findings will improve the prognosis and individualize the therapy of these diseases.