Location

Rochester, Minnesota

Contact

Weroha.Saravut@mayo.edu

Summary

Saravut (John) J. Weroha, M.D., Ph.D., studies overcoming platinum resistance in ovarian cancer. Although most patients initially respond to debulking surgery and platinum-based chemotherapy, the majority of patients experience cancer recurrences and, eventually, chemotherapy resistance. To address this, Dr. Weroha utilizes the largest known resource of patient-derived tumorgrafts (also referred to as patient avatars), developed with Paul Haluska Jr., M.D., Ph.D., and the Mayo Clinic Ovarian Cancer Specialized Program of Research Excellence.

Focus areas

  • Identify predictive markers of sensitivity to platinum chemotherapy and targeted therapy in order to help select the most appropriate treatment for patients and avoid toxicity from ineffective therapies
  • Personalize therapy by identifying and targeting aberrant gene pathways in acquired platinum resistance rather than treating all ovarian cancer patients with the same chemotherapies

Significance to patient care

Since recurrent ovarian cancer is generally not considered curable, testing new, front-line platinum-based combinations in avatars may lead to longer recurrence-free intervals and improve the cure rate for ovarian cancer patients.

Professional highlights

  • Ovarian Cancer Research Grant, Minnesota Ovarian Cancer Alliance, 2010
  • Liz Tilberis Early Career Award, Ovarian Cancer Research Fund, 2014

Recent Publications

See my publications

Professional Details

Academic Rank

  1. Assistant Professor of Medicine
  2. Assistant Professor of Oncology

Education

  1. Fellow - Medical Oncology, Clinical Investigator Program Mayo School of Graduate Medical Education, Mayo Clinic College of Medicine
  2. Internship/Residency - Internal Medicine, Clinical Investigator Program Mayo School of Graduate Medical Education, Mayo Clinic College of Medicine
  3. PhD - Pharmacology, Toxicology and Therapeutics University of Kansas School of Medicine
  4. MD University of Kansas School of Medicine
  5. BS - Cellular Biology, with Honors and Distinction University of Kansas
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BIO-20090094

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