Rochester, Minnesota


Oglesbee.Devin@mayo.edu Clinical Profile


The research activities of Devin Oglesbee, Ph.D., center on translational applications in diagnostics for the laboratory detection of inborn errors of metabolism and rare mitochondrial disorders. 

Particular areas of interest include developing new clinical assays and characterizing biomarkers for rare genetic disorders; developing new methodologies for improving and expanding newborn screening for genetic conditions; and organizing infrastructure, such as Mayo Clinic's Mitochondrial Disease Biobank, in order to expedite the progression of genetic research from bench to bedside.

Focus areas

  • Molecular diagnostics. Current translational research projects in molecular diagnostics include the clinical conversion of next-generation DNA sequencing technologies for the detection of mitochondrial diseases, lysosomal disorders and peroxisomal disorders, and the expansion of molecular assays to confirm newborn screening results from dried-blood spots.
  • Biomarkers for mitochondrial diseases. Dr. Oglesbee works toward clinically validating newly identified biomarker targets discovered by a multisite collaboration of researchers at Mayo Clinic, Columbia University and Massachusetts General Hospital.
  • Mitochondrial Disease Biobank. Expediting new applications for the diagnosis of rare genetic conditions requires accessible specimens for research and clinical validation. Dr. Oglesbee is a co-principal investigator of a Mayo Clinic infrastructure project, the Mitochondrial Disease Biobank. This biobank will help improve understanding and speed up detection of debilitating genetic conditions and permit the centralization of sufficient study material for testing new therapies.

Significance to patient care

The purpose of Dr. Oglesbee's research is to improve patient care and expedite the diagnostic process for people with rare genetic conditions. In addition, his research aims to provide new biomarkers for clinicians to use for therapeutic trials and for monitoring disease progression or diminution. 

Professional highlights

  • Vice-chair, College of American Pathologists-American College of Medical Genetics Biochemical and Molecular Genetics Resource Committee, College of American Pathologists, 2015-present
  • Co-director, Clinical Genome Sequencing Laboratory, Mayo Clinic, 2014-present
  • Fellow, American College of Medical Genetics and Genomics, 2009-present
  • Board certifications in clinical biochemical genetics and clinical molecular genetics, American Board of Medical Genetics and Genomics, 2007-present
  • Co-director, Biochemical Genetics Laboratory, Mayo Clinic, 2007-present


See my publications


Primary Appointment

  1. Laboratory Medicine and Pathology

Academic Rank

  1. Assistant Professor of Laboratory Medicine & Pathology
  2. Assistant Professor of Medical Genetics


  1. Fellow Molecular Genetics Laboratory, Laboratory Medicine & Pathology Programs, Programs in Rochester, Mayo School of Graduate Medical Education, Mayo Clinic College of Medicine
  2. Fellow Biochemical Genetics Laboratory, Laboratory Medicine & Pathology Programs, Programs in Rochester, Mayo School of Graduate Medical Education, Mayo Clinic College of Medicine
  3. PhD Institute of Molecular Biology, University of Oregon
  4. Post-Baccalaureate Program Université Lumière, Lyon
  5. BS - with honors University of Oregon

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