Rochester, Minnesota


Maleszewski.Joseph@mayo.edu Clinical Profile


Joseph J. Maleszewski, M.D., studies acquired and congenital forms of heart disease. His primary research focuses include neoplastic heart disease as well as the genetics and proteomics of both cardiomyopathies and aortic disease.

Focus areas

  • Molecular mechanisms involved in the formation of heart tumors, including cardiac myxoma, cardiac sarcomas and others
  • Proteomics and histopathologic risk stratification in cardiac amyloidosis
  • Genetic, proteomic and phenotypic features of cardiomyopathies, including dilated cardiomyopathy, hypertrophic cardiomyopathy and arrhythmogenic cardiomyopathy
  • Pathobiology of spontaneous coronary artery disease (SCAD)
  • Genotype-phenotype correlation of inherited forms of aortic diseases such as Marfan syndrome, Loeys-Dietz syndrome and congenitally bicuspid aortic valve
  • Molecular markers and histopathologic patterns of pulmonary vascular disease
  • Classification and nomenclature of congenital heart disease

Significance to patient care

Dr. Maleszewski's research aims to improve the diagnostic and prognostic approaches to cardiovascular and pulmonary disease.


See my publications


Administrative Appointment

  1. Consultant, Division of Anatomic Pathology, Department of Laboratory Medicine and Pathology
  2. Consultant, Division of Cardiovascular Diseases, Department of Internal Medicine
  3. Consultant, Division of Clinical Biochemistry & Immunology, Department of Laboratory Medicine and Pathology
  4. Consultant, Department of Medical Genetics

Academic Rank

  1. Associate Professor of Laboratory Medicine And Pathology
  2. Associate Professor of Medicine


  1. Fellow - Molecular Genetic Pathology Mayo School of Graduate Medical Education, Mayo Clinic College of Medicine
  2. Fellow - Cardiovascular Pathology Mayo School of Graduate Medical Education, Mayo Clinic College of Medicine
  3. Resident - Anatomic & Clinical Pathology The Johns Hopkins University School of Medicine
  4. MD College of Human Medicine, Michigan State University
  5. BS - Physiology with a Specialization in Health and Humanities Lyman Briggs School, Michigan State University

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