Location

Rochester, Minnesota

Contact

Kenderian.Saad@mayo.edu Clinical Profile

SUMMARY

The research of Saad J. Kenderian, M.B., Ch.B., and his team is centered on the development and optimization of novel-engineered T cell therapy approaches for the treatment of cancer. Using the immune system to treat cancer (immunotherapy) has emerged as a potent and potentially curative modality. The recent success of engineered T cell therapy highlights the potential for this technology as a new pillar in the treatment of hematological malignancies.

Focus areas

  • Modified cellular therapies. The major focus of Dr. Kenderian's research team is to develop safe and efficient next-generation modified cellular products and to extend their applications to the treatment of different hematological and solid tumors.
  • Resistance to immunotherapy. Despite the reported success of immunotherapy and engineered T cell therapy in the treatment of hematological malignancies, a significant percentage of patients do not respond. A key area of Dr. Kenderian's laboratory is to identify mechanisms of resistance to immunotherapy in chronic lymphocytic leukemia and other hematological cancers.
  • Allogeneic hematopoietic cell transplantation. Allogeneic transplantation remains the only potentially curative option in a number of hematological malignancies but is associated with high morbidity and mortality due to the development of graft-versus-host disease. Dr. Kenderian's laboratory is therefore investigating modified products to enhance the safety of allogeneic transplantation.
  • Combination immunotherapy. In order to enhance the efficacy and safety of modified T cell therapy, Dr. Kenderian's laboratory is testing the optimal development of combinatorial approaches with signal inhibitors, small molecule approach and other immunotherapeutic approaches.

Significance to patient care

Dr. Kenderian's team is focused on developing new, effective and safe immunotherapeutic options for patients with relapsed and refractory hematological malignancies. His team collaborates with other teams and centers within Mayo Clinic and has several research efforts in early-phase clinical trials.

Professional highlights

  • Recipient, Plenary presentation award, American Society for Blood and Marrow Transplantation, 2015 and 2016
  • Recipient, Alexandra J. Kefalides Memorial Award, Abramson Cancer Center, University of Pennsylvania, 2014
  • Recipient, Mayo Clinic Scholar award, 2013
  • Recipient, Hematology/Oncology Award, Outstanding Achievement, Mayo Clinic, 2013
  • Recipient, The Consummate Physician Award, McLaren Hospital, Michigan State University, 2009
  • Recipient, The Team Leader Award, McLaren Hospital, Michigan State University, 2009
  • Recipient, Outstanding Resident of the Year Award, McLaren Hospital, Michigan State University, 2007 and 2008

PUBLICATIONS

See my publications

PROFESSIONAL DETAILS

Joint Appointment

  1. Senior Associate Consultant, Department of Immunology

Academic Rank

  1. Assistant Professor of Immunology
  2. Assistant Professor of Medicine
  3. Assistant Professor of Oncology

EDUCATION

  1. Mayo Clinic Scholar - Immunotherapy, Chimeric Antigen Receptor T Cell Therapy University of Pennsylvania School of Medicine
  2. Chief Fellow - Hematology and Medical Oncology Mayo Clinic, School of Graduate Medical Education
  3. Fellow - Hematology, Medical Oncology, Bone Marrow Transplantation Mayo Clinic, School of Graduate Medical Education
  4. Chief Medical Resident McLaren Regional Medical Center, Michigan State University
  5. Residency - Internal Medicine McLaren Regional Medical Center, Michigan State University
  6. Rotating Internship University of Baghdad School of Medicine
  7. MB ChB University of Baghdad School of Medicine
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BIO-20206512

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