Rochester, Minnesota




The research interests of Steven N. Hart, Ph.D., are in aggregating and interpreting next-generation DNA sequencing technologies. As a collaborative scientist in the Center for Individualized Medicine, Dr. Hart leads the development of the GenomeGPS analysis toolkit, the DNA sequencing work flow used by many Mayo Clinic researchers as they try to understand the genetic basis for disease. Dr. Hart also works in close collaboration with information technology groups to build applications to help classify, prioritize and manipulate large genomics datasets.

Focus areas

  • Application development. Dr. Hart has developed several bioinformatics tools that identify large genetic rearrangements, present complex data in meaningful ways and simulate genomics data.
  • Clinical Genome Sequencing Laboratory. As associate director of bioinformatics in Mayo's Clinical Genome Sequencing Laboratory, Dr. Hart oversees the bioinformatics components necessary for transforming new sequencing-based assays into clinical tests.
  • Cancer genomics. Dr. Hart works toward integrated next-generation sequencing data analysis of multiple genomic features, such as gene expression, copy number and mutations, to better understand their association with patient outcomes and identify potential therapies.
  • Inherited cancer risk. Dr. Hart's team is sequencing the genes of thousands of samples to identify new genes that predispose people to develop breast, ovarian or prostate cancer.

Significance to patient care

Dr. Hart is on the forefront of bringing new high-throughput technologies into clinical practice. These technologies can identify disease-causing mutations, assess individual genetic risk for developing cancers, optimize drug dosing for patients with certain genetic variations and much more.

Professional highlights

  • Distinguished Poster Award for Postdoctoral Research Fellow, Mayo Clinic Young Investigator Research Symposium, 2012
  • Madison & Lila Self Graduate Fellowship, Kansas University Medical Center, 2006-2011


See my publications


Primary Appointment

  1. Associate Consultant I, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research

Academic Rank

  1. Assistant Professor of Biomedical Informatics


  1. PhD - Pharmacology University of Kansas Medical Center
  2. BS - Biotechnology Missouri Western State University

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