Research in the laboratory of Pritam Das, Ph.D., focuses on the role of inflammation, the brain's innate immune system, and changes with aging in the development and progression of Alzheimer's disease. Specifically, Dr. Das' team is investigating how such inflammatory pathways may impact the development or progression of Alzheimer's disease.
Dr. Das' research team has generated a wealth of data showing that inflammatory markers in the brain could prevent amyloid deposition in the brain using mouse models of Alzheimer's disease. Based on this work, Dr. Das' team hypothesizes that it may be possible to harness these immunomodulatory pathways to potentially slow or prevent progression of Alzheimer's disease.
- Role of brain inflammation on amyloid-beta clearance mechanisms
- Chemokines and chemokine receptor signaling in the central nervous system
- Function of microglial TREM2 signaling on central nervous system health and disease
Significance to patient care
Alzheimer's disease is a devastating neurological disorder that continues to afflict the growing aging population. Dr. Das is determined not only to develop therapies to cure this devastating disease but also to find ways to prevent it for future generations.