Rochester, Minnesota


Brozovich.Frank@mayo.edu Clinical Profile


How changes in the regulation of smooth muscle contractile proteins contribute to human cardiovascular disease is unclear. The research program of Frank V. Brozovich, M.D., Ph.D., aims to identify changes in protein structure and/or cell signaling that result in abnormal contractility, including pulmonary hypertension and heart failure.

Methods used in Dr. Brozovich's laboratory include transgenic, molecular biological, biochemical and biophysical experimental techniques.

Focus areas

Using the above techniques, experiments focus on:

  • Identifying alterations in signaling pathways that contribute to cardiovascular disease processes
  • Defining protein-protein interactions and protein phosphorylation in the NO-PKG pathway that regulate signaling and are important for muscle contractility

Significance to patient care

The long-term objective of Dr. Brozovich's laboratory is to identify new targets for rational drug design for the treatment of vascular disease.


See my publications


Administrative Appointment

  1. Consultant, Division of Cardiovascular Diseases, Department of Internal Medicine
  2. Consultant, Department of Physiology & Biomedical Engineering
  3. Consultant, Department of Biochemistry and Molecular Biology

Academic Rank

  1. Professor of Medicine
  2. Professor of Physiology


  1. Clinical Fellowship Department of Cardiology, Graduate Hospital, University of Pennsylvania
  2. Chief Medical Resident Department of Medicine, Brockton/West Roxbury Veterans Administration Medical Center, Brockton, MA, Harvard Medical School
  3. Internship - Internal Medicine Department of Medicine, Beth Israel Hospital, Harvard Medical School
  4. Postdoctoral Research Fellowship Cardiovascular Division, Department of Medicine, Beth Israel Hospital, Harvard Medical School
  5. Resident - Internal Medicine Department of Medicine, Beth Israel Hospital, Harvard Medical School
  6. Predoctoral Research Fellow Department of Physiology and Biophysics, University of Washington, Seattle
  7. MD/PhD University of Washington, Seattle
  8. Predoctoral Research Fellow Department of Bioengineering, University of Washington, Seattle
  9. MSE University of Washington, Seattle
  10. BSE University of Washington, Seattle

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