Overview

The Mayo Clinic Metabolomics Resource Core, directed by K. Sreekumaran Nair, M.D., Ph.D., is one of six National Institutes of Health (NIH) Common Fund-supported metabolomics centers in United States. It furthers metabolomics research in disease diagnosis and prevention by assisting clinical and basic science investigators to profile the metabolites involved in micro (cellular) and macro (organ) physiology.

Metabolite dynamics are increasingly becoming better predictors of cellular and organ function when compared with the traditional steady state composition of the metabolic pool and associated concentrations. The Mayo Clinic Metabolomics Resource Core (MCMRC) has a successful track record in stable isotope-labeled metabolic studies in both human and animal models.

Dr. Nair pioneered the use of stable isotope labeling to understand the mechanism of amino acid synthesis in response to insulin therapy in people with type 2 diabetes. These studies led to a fundamental systems-level modeling of insulin's effect on protein synthesis rates in liver and muscle.

NIH funding has enabled the MCMRC to expand and offer its metabolic systems modeling expertise to investigators worldwide.

Consultation

The MCMRC supports investigators in the design and execution of the dynamic metabolomics studies, provides bioinformatics analysis of the resulting spectral data, and collaborates with the investigators to provide statistical and mathematical expertise needed for systems level modeling.

Technology

The MCMRC maintains state-of-the-art technology, including:

  • Mass spectrometers coupled with liquid chromatography (LC) and gas chromatography (GC) for performing metabolomics experiments
  • A laboratory information management system that captures study metadata, study samples, sample processing history and final results
  • The bioinformatics and mathematical modeling infrastructure for visualizing and modeling the complex omics level interactions with the phenotype

Grants, training and data sharing

The MCMRC seeds innovative metabolomics projects by offering assistance through Pilot and Feasibility Program grants. It recruits and trains the next generation of metabolomics investigators by reaching into the scientific community via seminars, online tutorials and graduate-level courses. The MCMRC works with the Metabolomics Data Repository and Coordinating Center to develop data-sharing standards for dynamic metabolomics experiments.

Acknowledgement

NIH Public Access Policy requires that all publication that results from NIH funding be uploaded to PubMed Central. Review the process for uploading publications.

Awardees must cite the Mayo Clinic Metabolomics Resource Core grant as a funding source in any resulting publications. Use this language:

This publication was made possible by Mayo Clinic Metabolomics Resource Core through grant number U24DK100469 from the National Institute of Diabetes and Digestive and Kidney Diseases and originates from the National Institutes of Health Director's Common Fund.