The Model Systems Core within the Translational Polycystic Kidney Disease (PKD) Center at Mayo Clinic develops and makes available PKD model systems and technologies to PKD researchers at Mayo and at other institutions. These technologies are used to evaluate potential therapies and determine the function of PKD proteins.
Model systems in the core include C. elegans, zebrafish and rodents. The core builds on existing Mayo Clinic expertise in these particular organisms, especially as in vivo models.
- C. elegans PKD-targeted services. C. elegans is a powerful model for characterizing the physiological roles of PKD genes in their native cellular environment. Five specific C. elegans-related services are offered. Learn more.
- Zebrafish PKD-targeted services. The zebrafish is well-established as a model system for studying PKD, and Mayo has an expanding group of faculty exploring the use of zebrafish for kidney development and disease research. Five zebrafish-focused services are offered. Learn more.
- Rodent PKD-targeted services. Rodent models of PKD are ideal for testing promising therapies and for studying renal and extrarenal disease pathology. Four specific rodent-related services are offered. Learn more.